Recent multi-omics studies, including proteomics, transcriptomics, genomics, and
metabolomics have revealed the critical role of post-translational modifications (PTMs) in the …

The modification of proteins by the addition of ubiquitin and other ubiquitin-like proteins
(UBLs) is involved in a wide range of cellular processes including cell cycle progression, the …

SIPR α on macrophages binds with CD47 to resist proengulfment signals, but how the
downstream signal of SIPR α controls tumor-infiltrating macrophages (TIMs) is still poorly …

Background Paclitaxel (PTX) treatment resistance is an important factor leading to poor
prognosis in triple-negative breast cancer (TNBC), therefore there is an urgent need to …

Background & Aims Cholangiocarcinoma (CCA) comprises a heterogeneous group of
malignant tumors associated with dismal prognosis. Alterations in post-translational …

Breast carcinoma has one of the highest incidence rates (11.7%), with significant clinical
heterogeneity. Although conventional chemotherapy and surgical resection are the current …

Cholangiocarcinoma (CCA) comprises diverse tumors of the biliary tree and is characterized
by late diagnosis, short-term survival, and chemoresistance. CCAs are mainly classified …

Synthetic engineering of viral vectors such as adeno-associated virus (AAV) is crucial to
overcome host transduction barriers observed during clinical gene therapy. We reasoned …

Introduction: Neddylation is a highly dynamic and reversible post-translational modification.
The abnormality of neddylation has previously been shown to be closely related to some …

Drug resistance is a major obstacle faced by therapist in treating HIV infected patients. The
reason behind these phenomena is either protein mutation or the changes in gene …