Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus
S Khosla, P Samakkarnthai, DG Monroe… - Nature Reviews …, 2021 - nature.com
Fracture risk is increased in patients with type 2 diabetes mellitus (T2DM). In addition, these
patients sustain fractures despite having higher levels of areal bone mineral density, as …
patients sustain fractures despite having higher levels of areal bone mineral density, as …
Meta-analysis of diabetes mellitus-associated differences in bone structure assessed by high-resolution peripheral quantitative computed tomography
Abstract Purpose of Review Diabetes mellitus is defined by elevated blood glucose levels
caused by changes in glucose metabolism and, according to its pathogenesis, is classified …
caused by changes in glucose metabolism and, according to its pathogenesis, is classified …
The clinical application of high-resolution peripheral computed tomography (HR-pQCT) in adults: state of the art and future directions
JP Van den Bergh, P Szulc, AM Cheung… - Osteoporosis …, 2021 - Springer
High-resolution peripheral computed tomography (HR-pQCT) was developed to image bone
microarchitecture in vivo at peripheral skeletal sites. Since the introduction of HR-pQCT in …
microarchitecture in vivo at peripheral skeletal sites. Since the introduction of HR-pQCT in …
Altered tissue composition, microarchitecture, and mechanical performance in cancellous bone from men with type 2 diabetes mellitus
HB Hunt, AM Torres, PM Palomino… - Journal of Bone and …, 2019 - academic.oup.com
People with type 2 diabetes mellitus (T2DM) have normal‐to‐high BMDs, but,
counterintuitively, have greater fracture risks than people without T2DM, even after …
counterintuitively, have greater fracture risks than people without T2DM, even after …
High‐fat diet‐induced obesity augments the deleterious effects of estrogen deficiency on bone: Evidence from ovariectomized mice
Several epidemiological studies have suggested that obesity complicated with insulin
resistance and type 2 diabetes exerts deleterious effects on the skeleton. While obesity …
resistance and type 2 diabetes exerts deleterious effects on the skeleton. While obesity …
Determinants of bone material strength and cortical porosity in patients with type 2 diabetes mellitus
Context Reduced bone material strength index (BMSi) and increased cortical porosity (CtPo)
have emerged as potentially contributing to fracture risk in type 2 diabetes mellitus (T2DM) …
have emerged as potentially contributing to fracture risk in type 2 diabetes mellitus (T2DM) …
Association between knee alignment, osteoarthritis disease severity, and subchondral trabecular bone microarchitecture in patients with knee osteoarthritis: a cross …
X Han, J Cui, K Xie, X Jiang, Z He, J Du, L Chu… - Arthritis Research & …, 2020 - Springer
Background Knee osteoarthritis (OA) is a common disabling disease involving the entire
joint tissue, and its onset and progression are affected by many factors. However, the current …
joint tissue, and its onset and progression are affected by many factors. However, the current …
Peripheral neuropathy as a component of skeletal disease in diabetes
AT Beeve, JM Brazill, EL Scheller - Current Osteoporosis Reports, 2019 - Springer
Abstract Purpose of Review The goal of this review is to explore clinical associations
between peripheral neuropathy and diabetic bone disease and to discuss how nerve …
between peripheral neuropathy and diabetic bone disease and to discuss how nerve …
The diabetes-fracture association in women with type 1 and type 2 diabetes is partially mediated by falls: a 15-year longitudinal study
This study evaluated mediators of fracture risk in postmenopausal women with type 1 (T1D)
and type 2 diabetes (T2D), over a 15-year follow-up period. This study provides evidence …
and type 2 diabetes (T2D), over a 15-year follow-up period. This study provides evidence …
Advanced glycation endproducts and bone quality: practical implications for people with type 2 diabetes
KF Moseley, Z Du, SE Sacher… - Current Opinion in …, 2021 - journals.lww.com
Hyperglycemia drives systemic, circulating AGE formation with subsequent accumulation in
the bone tissue. In those with T2D, studies suggest that AGEs diminish fracture resistance …
the bone tissue. In those with T2D, studies suggest that AGEs diminish fracture resistance …