The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …

Poly (ADP-ribosyl) ation is a post-translational modification of proteins. During this process,
molecules of ADP-ribose are added successively on to acceptor proteins to form branched …

Cold Spring Harbor Symposia on Quantitative Biology, Volume LXV.© 2000 Cold Spring
Harbor Laboratory Press 0-87969-605-2/00. 127 bile glycosyl bond of 7 …

p53 binding protein 1 (53BP1), a protein proposed to function as a transcriptional coactivator
of the p53 tumor suppressor, has BRCT domains with high homology to the Saccharomyces …

It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase,
and TIN2 have no recognized orthologs in budding yeast. Here, we describe a human …

DNA single-strand breaks can arise indirectly, as normal intermediates of DNA base
excision repair, or directly from damage to deoxyribose. Because single-strand breaks are …

53BP1 binds to the tumor suppressor protein p53 and has a potential role in DNA damage
responses. We used small interfering RNA (siRNA) directed against 53BP1 in mammalian …

Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells.
Following genotoxic stress, diverse molecular signals must be integrated to establish …

DNA double-strand breaks (DSBs) are introduced in cells by ionizing radiation and reactive
oxygen species. In addition, they are commonly generated during V (D) J recombination, an …

The tumor suppressor p53 binding protein 1 (53BP1) binds to the DNA-binding domain of
p53 and enhances p53-mediated transcriptional activation. 53BP1 contains two breast …