NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Significance: Cancer cells are stabilized in an undifferentiated state similar to stem cells.
This leads to profound modifications of their metabolism, which further modifies their …

Sirtuin 3 (SIRT3), the major deacetylase in mitochondria, plays a crucial role in modulating
oxygen reactive species (ROS) and limiting the oxidative damage in cellular components …

Osteoarthritis (OA) is a major cause of disability in the elderly population and represents a
significant public health problem and socioeconomic burden worldwide. However, no …

L-lactate plays a critical role in learning and memory. Studies in rats showed that
administration of exogenous L-lactate into the anterior cingulate cortex and hippocampus …

Autophagy is a critical cellular homeostatic mechanism, and its dysfunction is linked to
invasive breast carcinoma (BRCA). Recently, several omics methods have been applied to …

Nicotinamide adenine dinucleotide (NAD+) is an essential biomolecule involved in many
critical processes. Its role as both a driver of energy production and a signaling molecule …

Ovarian cancer is the most malignant gynecologic cancer among women worldwide.
Cryptotanshinone (CT), isolated from Salvia miltiorrhiza Bunge, has been identified as a …

Melanoma and its associated alterations in cellular pathways have been growing areas of
interest in research, especially as specific biological pathways are being elucidated. Some …