Berberine protects against ischemia-reperfusion injury: a review of evidence from animal models and clinical studies

DQ Liu, SP Chen, J Sun, XM Wang, N Chen… - Pharmacological …, 2019 - Elsevier
Abstract Ischemia-reperfusion (I/R) injury is accompanied with high morbidity and mortality
and has seriously negative social and economic influences. Unfortunately, few effective …

Estrogen and estrogen receptors in kidney diseases

HY Ma, S Chen, Y Du - Renal failure, 2021 - Taylor & Francis
Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to
global health within this century. Studies have suggested that estrogen and estrogen …

Berberine slows the progression of prediabetes to diabetes in zucker diabetic fatty rats by enhancing intestinal secretion of glucagon-like peptide-2 and improving the …

Y Wang, H Liu, M Zheng, Y Yang, H Ren… - Frontiers in …, 2021 - frontiersin.org
Background Berberine is a plant alkaloid that has multiple beneficial effects against intestine
inflammation. In our previous study, we have found that berberine also possesses an …

Berberine promotes the viability of random skin flaps via the PI3K/Akt/eNOS signaling pathway

J Chen, Z Jiang, X Liu, K Wang, W Fan… - Phytotherapy …, 2023 - Wiley Online Library
Random skin flaps are often used in reconstruction operations. However, flap necrosis is still
a common postoperative complication. Here, we investigated whether berberine …

The relationship between serum trace elements and oxidative stress of patients with different types of cancer

Y Yang, C Dai, X Chen, J Feng - Oxidative Medicine and …, 2021 - Wiley Online Library
Objective. Many studies have identified causal and promotive roles of oxidative stress (OxS)
and oxidative damage caused by OxS in the occurrence and progression of cancer. Many …

Protective effects of berberine on various kidney diseases: emphasis on the promising effects and the underlined molecular mechanisms

EHM Hassanein, IM Ibrahim, EK Abd-Alhameed… - Life Sciences, 2022 - Elsevier
Berberine (BBR) is a pentacyclic benzylisoquinoline alkaloid that can be found in diversity of
medicinal plants. BBR has a wide range of pharmacological bioactivities, in addition when …

Berberine inhibits ferroptosis and stabilizes atherosclerotic plaque through NRF2/SLC7A11/GPX4 pathway

T Wang, L Yu, J Zheng, X Han, B Jin, C Hua… - Chinese Journal of …, 2024 - Springer
Objective To investigate potential mechanisms of anti-atherosclerosis by berberine (BBR)
using ApoE−/− mice. Methods Eight 8-week-old C57BL/6J mice were used as a blank …

Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats

J Zhang, L Wang, D Gong… - Molecular …, 2020 - spandidos-publications.com
The aim of the present study was to investigate whether the diabetic kidney is more
susceptible to ischemia/reperfusion (I/R) injury, and identify the potential mechanisms …

Berberine affords protection against oxidative stress and apoptotic damage in F1 generation of wistar rats following lactational exposure to chlorpyrifos

E Seth, AU Ahsan, S Kaushal, S Mehra… - Pesticide Biochemistry …, 2021 - Elsevier
Abstract Chlorpyrifos (0, 0-diethyl 0-(3, 5, 6-trichloro-2-pyridinyl)-phosphorothioate;(CPF)) is
a widely used lipophilic organophosphorus insecticide that primarily manifests into central …

A Mechanistic Review on How Berberine Use Combats Diabetes and Related Complications: Molecular, Cellular, and Metabolic Effects

VR Askari, K Khosravi, V Baradaran Rahimi, S Garzoli - Pharmaceuticals, 2023 - mdpi.com
Berberine (BBR) is an isoquinoline alkaloid that can be extracted from herbs such as Coptis,
Phellodendron, and Berberis. BBR has been widely used as a folk medicine to treat various …