Neuroinflammatory mediators in acquired epilepsy: an update

Y Chen, MM Nagib, N Yasmen, MN Sluter… - Inflammation …, 2023 - Springer
Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …

Neuroinflammation in epileptogenesis: from pathophysiology to therapeutic strategies

W Li, J Wu, Y Zeng, W Zheng - Frontiers in Immunology, 2023 - frontiersin.org
Epilepsy is a group of enduring neurological disorder characterized by spontaneous and
recurrent seizures with heterogeneous etiology, clinical expression, severity, and prognosis …

An update on the novel methods for the discovery of antiseizure and antiepileptogenic medications: where are we in 2024?

A Talevi, C Bellera - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Despite the availability of around 30 antiseizure medications, 1/3 of patients
with epilepsy fail to become seizure-free upon pharmacological treatment. Available …

Identification of biomarkers associated with immune scores in diabetic retinopathy

Y Zhang, W Zhu, J Wang, Y Zuo - Frontiers in Endocrinology, 2023 - frontiersin.org
Background Diabetic retinopathy (DR) causes irreversible visual impairment in diabetes
mellitus (DM) patients. Immunity played a crucial role in DR. Nevertheless, the triggering …

The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders

MN Sluter, Q Li, N Yasmen, Y Chen… - Experimental …, 2023 - journals.sagepub.com
The cyclooxygenase (COX)/prostaglandin E2 (PGE2) signaling pathway has emerged as a
critical target for anti-inflammatory therapeutic development in neurological diseases …

Novel, brain-permeable, cross-species benzothiazole inhibitors of microsomal prostaglandin E synthase-1 (MPGES-1) dampen neuroinflammation in vitro and in vivo

MN Sluter, R Bhuniya, X Yuan… - ACS Pharmacology & …, 2023 - ACS Publications
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme of the
cyclooxygenase (COX) cascade that generates prostaglandin E2 (PGE2) during …

[HTML][HTML] Effect of quercetin against pilocarpine-induced epilepsy in mice

WK Abdulsahib, MY Al-Radeef - Journal of Advanced …, 2024 - journals.lww.com
Globally, an estimated 50 million people are affected by epilepsy, a persistent,
noncommunicable neurological ailment. Quercetin (QR) is a prevalent flavonoid substance …

[PDF][PDF] Evaluation of the anticonvulsant properties of flurbiprofen in pilocarpine-induced convulsions in mice

N Albrefkani, N Ahmed - Baghdad Journal of Biochemistry and Applied …, 2023 - iasj.net
Methods: Twenty-five mature male mice were divided into five groups for the study. To
prevent peripheral cholinergic activation, mice in each group were injected intraperitoneally …