Refining glioblastoma surgery through the use of intra-operative fluorescence imaging agents

O Netufo, K Connor, LP Shiels, KJ Sweeney, D Wu… - Pharmaceuticals, 2022 - mdpi.com
Glioblastoma (GBM) is the most aggressive adult brain tumour with a dismal 2-year survival
rate of 26–33%. Maximal safe resection plays a crucial role in improving patient progression …

Biomarkers in tumors of the central nervous system–a review

D Scheie, HHA Kufaishi, H Broholm, EL Lund… - Apmis, 2019 - Wiley Online Library
Until recently, diagnostics of brain tumors were almost solely based on morphology and
immunohistochemical stainings for relatively unspecific lineage markers. Although certain …

Racial and socioeconomic disparities in glioblastoma outcomes: A single‐center, retrospective cohort study

D Estevez‐Ordonez, M Abdelrashid, E Coffee… - Cancer, 2023 - Wiley Online Library
Background Glioblastoma (GBM) is the most common malignant primary brain tumor.
Emerging reports have suggested that racial and socioeconomic disparities influence the …

Fluid attenuation in non‐contrast‐enhancing tumor (nCET): an MRI Marker for Isocitrate Dehydrogenase (IDH) mutation in Glioblastoma

SH Patel, PP Batchala, TJE Muttikkal… - Journal of neuro …, 2021 - Springer
Purpose The WHO 2016 update classifies glioblastomas (WHO grade IV) according to
isocitrate dehydrogenase (IDH) gene mutation status. We aimed to determine MRI-based …

Ventricular entry during surgical resection is associated with intracranial leptomeningeal dissemination in glioblastoma patients

F Battista, G Muscas, F Dinoi, D Gadda… - Journal of Neuro …, 2022 - Springer
Purpose Glioblastoma (GBM) is associated with a poorer prognosis when leptomeningeal
dissemination (LMD) occurs. Recently, the role of both ventricular entry (VE) during surgery …

The predominant expression of cancer stem cell marker ALDH1A3 in tumor infiltrative area is associated with shorter overall survival of human glioblastoma

C Gan, D Pierscianek, N El Hindy, Y Ahmadipour… - BMC cancer, 2020 - Springer
Background ALDH1A3 is a cancer stem cell marker in neoplasms including glioblastoma
(GBM). However, the comprehensive role of ALDH1A3 in GBM remains unclear. This study …

Improved 3-year survival rates for glioblastoma multiforme are associated with trends in treatment: analysis of the national cancer database from 2004 to 2013

J Zreik, FM Moinuddin, YU Yolcu, MA Alvi… - Journal of neuro …, 2020 - Springer
Purpose Glioblastoma multiforme (GBM) is a common and aggressive malignancy
associated with poor prognosis. Characteristics and treatment of long-term survivors are of …

Red blood cell distribution width to platelet ratio substantiates preoperative survival prediction in patients with newly-diagnosed glioblastoma

M Schneider, N Schäfer, S Apallas, AL Potthoff… - Journal of neuro …, 2021 - Springer
Object The conception of individual patient-adjusted treatment strategies is constantly
emerging in the field of neuro-oncology. Systemic laboratory markers may allow insights into …

Comorbid medical conditions as predictors of overall survival in glioblastoma patients

MT Carr, CJ Hochheimer, AK Rock, A Dincer… - Scientific Reports, 2019 - nature.com
Glioblastoma (GBM) is an aggressive central nervous system tumor with a poor prognosis.
This study was conducted to determine any comorbid medical conditions that are associated …

[HTML][HTML] Comprehensive molecular characterization of long-term glioblastoma survivors

H Xu, X Chen, Y Sun, X Hu, X Zhang, Y Wang, Q Tang… - Cancer Letters, 2024 - Elsevier
Abstract Fewer than 5% glioblastoma (GBM) patients survive over five years and are termed
long-term survivors (LTS), yet their molecular background is unclear. The present cohort …