Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2,
BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional …

All multicellular organisms rely on differential gene transcription regulated by genomic
enhancers, which function through cofactors that are recruited by transcription factors …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Elongin is a heterotrimeric elongation factor for RNA polymerase (Pol) II transcription that is
conserved among metazoa. Here, we report three cryo-EM structures of human Elongin …

Based on in vitro studies, it has been demonstrated that the DSIF complex, composed of
SPT4 and SPT5, regulates the elongation stage of transcription catalyzed by RNA …

Gene transcription by RNA polymerase II (Pol II) is under control of promoters and distal
regulatory elements known as enhancers. Enhancers are themselves transcribed by Pol II …

Transcription elongation has emerged as a regulatory hub in gene expression of
metazoans. A major control point occurs during early elongation before RNA polymerase II …

Summary RNA polymerase II (RNA Pol II) subunits are thought to be involved in various
transcription-associated processes, but it is unclear whether they play different regulatory …

Transcription elongation by RNA polymerase II (Pol II) has emerged as a regulatory hub in
gene expression. A key control point occurs during early transcription elongation when Pol II …