Aging biology and novel targets for drug discovery

DG Le Couteur, AJ McLachlan, RJ Quinn… - … Series A: Biomedical …, 2012 - academic.oup.com
Despite remarkable technological advances in genetics and drug screening, the discovery
of new pharmacotherapies has slowed and new approaches to drug development are …

Cognitive training program to improve working memory in older adults with MCI

L Hyer, C Scott, MM Atkinson, CM Mullen… - Clinical …, 2016 - Taylor & Francis
Objectives: Deficits in working memory (WM) are associated with age-related decline. We
report findings from a clinical trial that examined the effectiveness of Cogmed, a …

Testing of geroprotectors in experiments on cell cultures: pros and cons

AN Khokhlov, GV Morgunova - 2017 - books.rsc.org
According to the classic definition of aging we share, it is a combination of changes in an
organism leading to an increase in the probability of its death (rate of mortality). 1–4 It should …

A vascular theory of aging

DG Le Couteur, EG Lakatta - Journals of Gerontology Series A …, 2010 - academic.oup.com
Advancing age has usually been considered to be an unmodifiable risk factor for
atherosclerosis and therefore dismissed as therapeutically irrelevant in comparison with …

Adaptive senectitude: the prolongevity effects of aging

DG Le Couteur, SJ Simpson - Journals of Gerontology Series A …, 2011 - academic.oup.com
In the past, it has been assumed that all the biological and medical changes that occur in old
age are deleterious. It has therefore been concluded that treatment and prevention of such …

[图书][B] Psychological treatment of older adults: A holistic model

L Hyer - 2014 - books.google.com
" This is one of the best mental health and aging books I have ever read.[It] is one that I will
turn to often in my teaching of doctoral students, and in my work with older adults. One of the …

Evaluating participatory initiatives in South Africa: not just processes but outcomes too

J Brown - Sage Open, 2014 - journals.sagepub.com
The participatory model of management for natural resources, particularly water, rapidly
became a global phenomenon in the early part of the 21st century. In many developing and …

Extending the human life span: An exploratory study of pro-and anti-longevity attitudes

N Kogan, J Tucker, M Porter - The International Journal of …, 2011 - journals.sagepub.com
Successful efforts by biologists to substantially increase the life span of non-human animals
has raised the possibility of extrapolation to humans, which in turn has given rise to …

[PDF][PDF] Neuromodulatory potential of aqueous extracts of cumin, cinnamon: evidence from rotenone model in drosophila: implications to Parkinson's disease

SV Rao, GM Muralidhara, PS Rajini - International Journal of …, 2016 - researchgate.net
ABSTRACT AIM: Spice extracts and their bioactive molecules have been well recognized for
their innumerable beneficial effects against various chronic diseases. However …

Anti-Aging Drugs: Where are We and Where are We Going?

AM Vaiserman, OV Lushchak - 2017 - books.rsc.org
Human longevity dramatically increased during the last century when implementation of
vaccinations, disinfectants and antibiotics led to a substantial reduction of infectious …