Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Misfolding and aggregation of disease-specific proteins, resulting in the formation of
filamentous cellular inclusions, is a hallmark of neurodegenerative disease with …

The recently presented Azalea Hypothesis for Alzheimer's disease asserts that iron
becomes sequestered, leading to a functional iron deficiency that contributes to …

Recently, proposals have attempted to reclassify Lewy body diseases in vivo by merging the
long-established clinicopathological entities of Parkinson's disease (PD), Parkinson's …

Autophagic impairment was identified in many lysosomal storage diseases and adult
neurodegenerative diseases. It seems that this defect could be directly related to the …

Research into the pathophysiology of Parkinson's disease (PD) is a fast-paced pursuit, with
new findings about PD and other synucleinopathies being made each year. The …

Globoid cell leukodystrophy or Krabbe is a disease that affects children as well as adults
who have mutations in the gene encoding the enzyme galactosylceramidase …

Leukodystrophies are progressive single gene disorders affecting the white matter of the
brain. Several gene therapy trials are in progress to address the urgent unmet need for this …

Aggregation of α-synuclein (αSyn) and its accumulation as Lewy bodies play a central role
in the pathogenesis of Parkinson's disease (PD). However, the mechanism by which αSyn …

Neurodegenerative diseases are characterized by distinct protein aggregates, such as those
of α-synuclein and tau. Lysosomal defect is a key contributor to the accumulation and …