Covering: 1997 to early 2003 Recent studies on enzymes catalyzing the Diels–Alder
reaction, often named “Diels–Alderases”, clearly demonstrated the involvement of this …

Cytochrome P450 enzymes (P450s) are a superfamily of heme‐thiolate proteins widely
existing in various organisms. Due to their key roles in secondary metabolism, degradation …

The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …

The natural product lovastatin and its semisynthetic, more effective derivative, simvastatin,
are important drugs for the treatment of hypercholesterolemia. Here, we report the …

Several Aspergillus species are well-known for the production of a variety of organic acids.
In this study, a cloned based transcriptomics approach was used to identify genes crucial in …

Conspectus Biosynthesis of bioactive natural products frequently features oxidation at
multiple sites. Starting from a relatively reduced chemical scaffold that is assembled by …

Lovastatin, a cyclic nonaketide from Aspergillus terreus, is a hypercholesterolemic agent
and a precursor to simvastatin, a semi-synthetic cholesterol-lowering drug. The biosynthesis …

The genus of Monascus was nominated by van Tieghem in 1884, but its fermented product—
red mold rice (RMR), namely red yeast rice, has been used as folk medicines, food …

Several excellent books have been published that address one or more aspects of the
diverse field of industrial mycology, but none of them cover the entire process of fungal …

Monacolin K is a secondary metabolite synthesized by polyketide synthases (PKS) from
Monascus, and it has the same structure as lovastatin, which is mainly produced by …