[HTML][HTML] Engineering interferons and interleukins for cancer immunotherapy
Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …
various stimuli and act locally to regulate many aspects of human physiology and disease …
NK cell-based immunotherapy for cancer
F Fang, W Xiao, Z Tian - Seminars in immunology, 2017 - Elsevier
Natural killer (NK) cells can induce an antigen-independent immune response against
malignant cells. A growing number of scientific reports and clinical studies have shown …
malignant cells. A growing number of scientific reports and clinical studies have shown …
[HTML][HTML] Efficient production and enhanced tumor delivery of engineered extracellular vesicles
Extracellular vesicles (EV), including exosomes and microvesicles, are nano-sized
intercellular communication vehicles that participate in a multitude of physiological …
intercellular communication vehicles that participate in a multitude of physiological …
Curing HIV: seeking to target and clear persistent infection
Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …
Hepatic natural killer cells: organ-specific sentinels of liver immune homeostasis and physiopathology
The liver is considered a preferential tissue for NK cells residency. In humans, almost 50% of
all intrahepatic lymphocytes are NK cells that are strongly imprinted in a liver-specific …
all intrahepatic lymphocytes are NK cells that are strongly imprinted in a liver-specific …
Natural killer cells in liver disease and hepatocellular carcinoma and the NK cell‐based immunotherapy
P Liu, L Chen, H Zhang - Journal of Immunology Research, 2018 - Wiley Online Library
Nature killer (NK) cells play a critical role in host innate and adaptive immune defense
against viral infections and tumors. NK cells are enriched in liver hematopoietic cells with …
against viral infections and tumors. NK cells are enriched in liver hematopoietic cells with …
Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent
Abstract Interleukin (IL)-15 is essential for natural killer (NK), NKT and memory (m) CD8+ T
cell development and function, and is currently under investigation as an immunotherapeutic …
cell development and function, and is currently under investigation as an immunotherapeutic …
Maturing glycoproteomics technologies provide unique structural insights into the N-glycoproteome and its regulation in health and disease
The glycoproteome remains severely understudied because of significant analytical
challenges associated with glycoproteomics, the system-wide analysis of intact …
challenges associated with glycoproteomics, the system-wide analysis of intact …
[HTML][HTML] Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 …
C Bergamaschi, H Pandit, BA Nagy… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8+ T and
natural killer (NK) cells. Bioactive IL-15 is produced in the body as a heterodimeric cytokine …
natural killer (NK) cells. Bioactive IL-15 is produced in the body as a heterodimeric cytokine …
IL-2 and beyond in cancer immunotherapy
JM Wrangle, A Patterson, CB Johnson… - Journal of Interferon & …, 2018 - liebertpub.com
The development of the T-and natural killer (NK) cell growth factor IL-2 has been a sentinel
force ushering in the era of immunotherapy in cancer. With the advent of clinical grade …
force ushering in the era of immunotherapy in cancer. With the advent of clinical grade …