21st century natural product research and drug development and traditional medicines
Covering: 1987 to 2013 Natural products and related structures are essential sources of new
pharmaceuticals, because of the immense variety of functionally relevant secondary …
pharmaceuticals, because of the immense variety of functionally relevant secondary …
Revisiting gametocyte biology in malaria parasites
P Ngotho, AB Soares, F Hentzschel… - FEMS microbiology …, 2019 - academic.oup.com
Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito
vector. They are present at low levels in blood circulation and significant knowledge gaps …
vector. They are present at low levels in blood circulation and significant knowledge gaps …
The immune epitope database (IEDB): 2018 update
Abstract The Immune Epitope Database (IEDB, iedb. org) captures experimental data
confined in figures, text and tables of the scientific literature, making it freely available and …
confined in figures, text and tables of the scientific literature, making it freely available and …
A comprehensive subcellular atlas of the Toxoplasma proteome via hyperLOPIT provides spatial context for protein functions
Apicomplexan parasites cause major human disease and food insecurity. They owe their
considerable success to highly specialized cell compartments and structures. These …
considerable success to highly specialized cell compartments and structures. These …
The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA …
JF Armstrong, E Faccenda, SD Harding… - Nucleic acids …, 2020 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (www. guidetopharmacology. org) is
an open-access, expert-curated database of molecular interactions between ligands and …
an open-access, expert-curated database of molecular interactions between ligands and …
Generating high quality libraries for DIA MS with empirically corrected peptide predictions
Data-independent acquisition approaches typically rely on experiment-specific spectrum
libraries, requiring offline fractionation and tens to hundreds of injections. We demonstrate a …
libraries, requiring offline fractionation and tens to hundreds of injections. We demonstrate a …
Zika virus evolution and spread in the Americas
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects
have attracted a great deal of attention,, much remains unknown about ZIKV disease …
have attracted a great deal of attention,, much remains unknown about ZIKV disease …
The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle
INTRODUCTION Plasmodium parasites, the causative agent of malaria, are single-celled
organisms with distinct morphological developmental stages each specialized to inhabit …
organisms with distinct morphological developmental stages each specialized to inhabit …
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Abstract Development of a highly effective vaccine or antibodies for the prevention and
ultimately elimination of malaria is urgently needed. Here we report the isolation of a number …
ultimately elimination of malaria is urgently needed. Here we report the isolation of a number …
Simulation-based comprehensive benchmarking of RNA-seq aligners
Alignment is the first step in most RNA-seq analysis pipelines, and the accuracy of
downstream analyses depends heavily on it. Unlike most steps in the pipeline, alignment is …
downstream analyses depends heavily on it. Unlike most steps in the pipeline, alignment is …