Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly
people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense …

Age associated chronic inflammation is a major contributor to diseases with advancing age.
Adipose tissue function is at the nexus of processes contributing to age-related metabolic …

Adipose tissues in the hypodermis, the crucial stem cell reservoir in the skin and the
endocrine organ for the maintenance of skin homeostasis undergo significant changes …

Adipose tissue is a widely distributed organ that plays a critical role in age-related
physiological dysfunctions as an important source of chronic sterile low-grade inflammation …

Calorie restriction (CR) with adequate nutrient intake is a potential geroprotective
intervention. To advance this concept in humans, we tested the hypothesis that moderate …

We hypothesized that rapamycin (Rapa), acarbose (ACA), which both increase mouse
lifespan, and 17α‐estradiol, which increases lifespan in males (17aE2) all share common …

Ageing decreases the function of the immune system and increases susceptibility to some
chronic, infectious, and autoimmune diseases. Senescence cells, which produce …

Abstract Background Rapamycin (Rapa), acarbose (ACA), and 17α-estradiol (17aE2, males
only) have health benefits that increase lifespan of mice. Little is known about how these …