Intermolecular interactions involving aromatic rings are key processes in both chemical and
biological recognition. Their understanding is essential for rational drug design and lead …

Chemists, like artists, are able to construct new threedimensional objects, molecules and
materials that exist only in the mind of a person. I became interested in creating novel …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

Recognition of the DNA minor groove by pyrrole-imidazole polyamides - ScienceDirect Skip
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Abstract Zwischenmolekulare Wechselwirkungen unter Beteiligung aromatischer Ringe sind
Schlüsselvorgänge sowohl in chemischen als auch in biologischen Erkennungsprozessen …

Sequence-specific DNA-binding small molecules that can permeate cells could potentially
regulate transcription of specific genes. Simple pairing rules for the minor groove of the …

Abstract microRNAs are small, noncoding RNA that negatively regulate gene expression.
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …

MicroRNAs (miRNAs) play crucial roles in regulating gene expression in many cellular
contexts. Deregulation of miRNAs has been implicated in a number of disease conditions …

In this article we review thermodynamic studies designed to examine the interaction of low
molecular weight ligands or drugs with DNA. Over the past 10 years there has been an …

Developing a molecular view of the thermodynamics of DNA recognition is essential to the
design of ligands for regulating gene expression. In a first comprehensive attempt at …