The potential role of 'leaky gut'or reduced barrier function with increased intestinal
permeability has been considered an important factor in intestinal and extraintestinal …

Gastrointestinal (GI) symptoms have been described in a conspicuous percentage of
coronavirus disease 2019 (COVID-19) patients. This clinical evidence is supported by the …

There is converging and increasing evidence, but also uncertainty, for the role of abnormal
intestinal epithelial barrier function in the origin and development of a growing number of …

Introduction Patients with common variable immunodeficiency (CVID) have a high frequency
of inflammatory complications like autoimmune cytopenias, interstitial lung disease and …

A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
been identified as the pathogen responsible for the outbreak of a severe, rapidly developing …

Although vaccines are greatly mitigating the worldwide pandemic diffusion of SARS-Cov-2,
therapeutics should provide many distinct advantages as complementary approach to …

Celiac disease (CeD) is a chronic, autoimmune systemic disorder triggered by the ingestion
of gluten, a protein found in foods such as wheat, rye, and barley. The only effective …

For more than a century, certain bacterial infections that can breach the skin and mucosal
barriers have been implicated as common triggers of autoimmune syndromes, especially …

Coronaviruses constitute a significant threat to the human population. Severe acute
respiratory syndrome coronavirus-2, SARS-CoV-2, is a highly pathogenic human …

The published literature makes a very strong case that a wide range of disease morbidity
associates with and may in part be due to epithelial barrier leak. An equally large body of …