Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion,
intravasation, circulation, arrest/adhesion and extravasation require specific mechanical …

Circulating tumor cells (CTCs) exist in a microenvironment quite different from the solid
tumor tissue microenvironment. They are detached from matrix and exposed to the immune …

The bicuspid aortic valve (BAV) is the most common congenital valvular defect and a major
risk factor for secondary calcific aortic valve disease. While hemodynamics is presumed to …

Calcification is a prevalent disease in most fully developed countries and is predominantly
observed in heart valves and nearby vasculature. Calcification of either tissue leads to …

Bicuspid aortic valves (BAVs) generate flow abnormalities that may promote aortopathy.
While positive helix fraction (PHF) index, flow angle (θ), flow displacement (d) and wall …

Cardiovascular system diseases, as aortic valve stenosis, are the main cause of mortality
and morbidity among patients. There is still a room for enhancement of the diagnostic and …

Aortic valve calcification is an important cardiovascular disorder that deteriorates the
accurate functioning of the valve leaflets. The increasing stiffness due to the calcification …

The bicuspid aortic valve (BAV) generates wall shear stress (WSS) abnormalities in the
ascending aorta (AA) that may be responsible for the high prevalence of aortopathy in BAV …

The field of heart valve biomechanics is a rapidly expanding, highly clinically relevant area
of research. While most valvular pathologies are rooted in biomechanical changes, the …

Bicuspid aortic valve (BAV) is the most common type of congenital heart disease, occurring
in 0.5–2% of the population, where the valve has only two rather than the three normal …