In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …

The mRNA vaccine, a groundbreaking advancement in the field of immunology, has
garnered international recognition by being awarded the prestigious Nobel Prize, which has …

The stemness loss–associated dysregeneration of impaired alveolar type 2 epithelial (AT2)
cells abolishes the reversible therapy of idiopathic pulmonary fibrosis (IPF). We here report …

Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation
and effective translation. Despite some progress, delivery systems are still unable to fully …

Leveraging the extensive surface area of the lungs for gene therapy, the inhalation route
offers distinct advantages for delivery. Clinical nebulizers that employ vibrating mesh …

Among various mRNA carrier systems, lipid nanoparticles (LNPs) stand out as the most
clinically advanced. While current clinical trials of mRNA/LNP therapeutics mainly address …

Branching is a key structural parameter of polymers, which can have profound impacts on
physicochemical properties. It has been demonstrated that branching is a modulating factor …

Messenger RNA (mRNA) therapeutics have been widely employed as strategies for the
treatment and prevention of diseases. Amid the global outbreak of COVID-19, mRNA …

Much of current clinical interest has focused on mRNA therapeutics for the treatment of lung-
associated diseases, such as infections, genetic disorders, and cancers. However, the safe …

This review introduces the typical delivery process of messenger RNA (mRNA)
nanomedicines and concludes that the delivery involves a at least four-step SCER cascade …