NK cells mediate a crucial graft-versus-leukemia effect in haploidentical-HSCT to cure high-risk acute leukemia

F Locatelli, D Pende, M Falco, M Della Chiesa… - Trends in …, 2018 - cell.com
Natural killer (NK) cells are involved in innate defenses against viruses and tumors. Their
function is finely tuned by activating and inhibitory receptors. Among the latter, killer …

Where do we stand after decades of studying human cytomegalovirus?

F Gugliesi, A Coscia, G Griffante, G Galitska… - Microorganisms, 2020 - mdpi.com
Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging
to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging …

Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis

P Teira, M Battiwalla, M Ramanathan… - Blood, The Journal …, 2016 - ashpublications.org
Single-center studies have reported an association between early (before day 100)
cytomegalovirus (CMV) reactivation and decreased incidence of relapse for acute myeloid …

CD56dimCD57+ NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT

F Cichocki, S Cooley, Z Davis, TE DeFor, H Schlums… - Leukemia, 2016 - nature.com
We have recently described a specialized subset of human natural killer (NK) cells with a
CD56 dim CD57+ NKG2C+ phenotype that expand specifically in response to …

[HTML][HTML] Cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation is associated with a reduced risk of relapse in patients with acute …

K Takenaka, T Nishida, Y Asano-Mori, K Oshima… - Biology of Blood and …, 2015 - Elsevier
Cytomegalovirus (CMV) infection is a major infectious complication after allogeneic
hematopoietic cell transplantation (allo-HSCT). Recently, it was reported that CMV …

Clinical utility of natural killer cells in cancer therapy and transplantation

DA Knorr, V Bachanova, MR Verneris, JS Miller - Seminars in immunology, 2014 - Elsevier
Natural killer (NK) cells recognize deranged cells that display stress receptors or loss of
major histocompatibility complex (MHC) class I. During development, NK cells become …

[HTML][HTML] Cytomegalovirus (CMV) infection and risk of mortality in allogeneic hematopoietic stem cell transplantation (Allo-HSCT): A systematic review, meta-analysis …

E Giménez, I Torres, E Albert, JL Pinana… - American Journal of …, 2019 - Elsevier
Controversy surrounds the potential association between cytomegalovirus (CMV) infection
and increased risk of mortality after allogeneic hematopoietic stem cell transplantation (Allo …

Haploidentical allogeneic hematopoietic stem cell transplantation increases the risk of cytomegalovirus infection in adult patients with acute leukemia

CH Lin, YJ Su, CY Hsu, PN Wang… - Transplant Infectious …, 2019 - Wiley Online Library
Background Owing to the shortage of hematopoietic stem cells from matched sibling donors
(MSD) and matched unrelated donors (MUD), the number of patients undergoing …

[HTML][HTML] Risk factors for and the clinical impact of cytomegalovirus and Epstein-Barr virus infections in pediatric recipients of TCR-α/β–and CD19-depleted grafts

A Laberko, A Bogoyavlenskaya, L Shelikhova… - Biology of Blood and …, 2017 - Elsevier
Alpha/beta T cell and CD19 depletion are used to improve the outcomes of hematopoietic
stem cell transplantation (HSCT). We evaluated the burden of cytomegalovirus (CMV) and …

The clinical impact of cytomegalovirus infection following allogeneic hematopoietic cell transplantation: why the quest for meaningful prophylaxis still matters

ST Chan, AC Logan - Blood reviews, 2017 - Elsevier
Latent infection with human cytomegalovirus (CMV) is common. Functional immunity
effectively contains such latent infections; however, CMV reactivation may cause significant …