The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems

SE Leggett, AM Hruska, M Guo, IY Wong - Cell Communication and …, 2021 - Springer
The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …

Cancer metabolism and carcinogenesis

J Yang, C Shay, NF Saba, Y Teng - Experimental Hematology & Oncology, 2024 - Springer
Metabolic reprogramming is an emerging hallmark of cancer cells, enabling them to meet
increased nutrient and energy demands while withstanding the challenging …

Morphogenesis of biofilms in porous media and control on hydrodynamics

DL Kurz, E Secchi, R Stocker… - … Science & Technology, 2023 - ACS Publications
The functioning of natural and engineered porous media, like soils and filters, depends in
many cases on the interplay between biochemical processes and hydrodynamics. In such …

Unjamming and collective migration in MCF10A breast cancer cell lines

JH Kim, AF Pegoraro, A Das, SA Koehler… - Biochemical and …, 2020 - Elsevier
Each cell comprising an intact, healthy, confluent epithelial layer ordinarily remains
sedentary, firmly adherent to and caged by its neighbors, and thus defines an elemental …

Bridging the gap between collective motility and epithelial–mesenchymal transitions through the active finite voronoi model

J Huang, H Levine, D Bi - Soft Matter, 2023 - pubs.rsc.org
We introduce an active version of the recently proposed finite Voronoi model of epithelial
tissue. The resultant Active Finite Voronoi (AFV) model enables the study of both confluent …

Learning Collective Cell Migratory Dynamics from a Static Snapshot with Graph Neural Networks

H Yang, F Meyer, S Huang, L Yang, C Lungu… - PRX Life, 2024 - APS
Multicellular self-assembly into functional structures is a dynamic process that is critical in
the development of biological structures and diseases, including embryo development …

Nanostructured architectures promote the mesenchymal–epithelial transition for invasive cells

Z Wang, F Xia, M Labib, M Ahmadi, H Chen, J Das… - ACS …, 2020 - ACS Publications
Dynamic modulation of cellular phenotypes between the epithelial and mesenchymal states—
the epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) …

Fractal dimension to characterize interactions between blood and lymphatic endothelial cells

DP Jeong, D Montes, HC Chang… - Physical …, 2023 - iopscience.iop.org
Spatial patterning of different cell types is crucial for tissue engineering and is characterized
by the formation of sharp boundary between segregated groups of cells of different lineages …

3D aggregation of cells in packed microgel media

CD Morley, J Tordoff, CS O'Bryan, R Weiss… - Soft Matter, 2020 - pubs.rsc.org
In both natural and applied contexts, investigating cell self-assembly and aggregation within
controlled 3D environments leads to improved understanding of how structured cell …

Nanocoating of CsgA protein for enhanced cell adhesion and proliferation

C Yang, D Li, S Zang, Y Zhou, L Zhang… - Chinese Chemical …, 2023 - Elsevier
Immune rejection, poor biocompatibility and cytotoxicity have seriously stalled the
widespread application of biometallic materials. To overcome these problems, biometallic …