Clinical applications of attenuated MVA poxvirus strain
The highly attenuated poxvirus strain modified vaccinia virus Ankara (MVA) has reached
maturity as a vector delivery system and as a vaccine candidate against a broad spectrum of …
maturity as a vector delivery system and as a vaccine candidate against a broad spectrum of …
Genetically modified cancer vaccines: Current status and future prospects
X Hu, W Zhou, R Pi, X Zhao… - Medicinal Research …, 2022 - Wiley Online Library
Vaccines can stimulate the immune system to protect individuals from infectious diseases.
Moreover, vaccines have also been applied to the prevention and treatment of cancers. Due …
Moreover, vaccines have also been applied to the prevention and treatment of cancers. Due …
Evaluation of safety and efficacy of p53MVA vaccine combined with pembrolizumab in patients with advanced solid cancers
V Chung, FJ Kos, N Hardwick, Y Yuan, J Chao… - Clinical and …, 2019 - Springer
Background Vaccination of cancer patients with p53-expressing modified vaccinia Ankara
virus (p53MVA) has shown in our previous studies to activate p53-reactive T cells in …
virus (p53MVA) has shown in our previous studies to activate p53-reactive T cells in …
[HTML][HTML] Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs
D Kong, Z Wen, H Su, J Ge, W Chen, X Wang, C Wu… - Virology, 2012 - Elsevier
Nipah virus (NiV), a member of the Paramyxoviridae family, causes deadly encephalitis in
humans and huge economic losses to the pig industry. Here, we generated recombinant …
humans and huge economic losses to the pig industry. Here, we generated recombinant …
p53MVA Therapy in Patients with Refractory Gastrointestinal Malignancies Elevates p53-Specific CD8+ T-cell Responses
NR Hardwick, M Carroll, T Kaltcheva, D Qian… - Clinical Cancer …, 2014 - AACR
Purpose: To conduct a phase I trial of a modified vaccinia Ankara (MVA) vaccine delivering
wild-type human p53 (p53MVA) in patients with refractory gastrointestinal cancers …
wild-type human p53 (p53MVA) in patients with refractory gastrointestinal cancers …
[HTML][HTML] Heterogeneous responses in hepatocellular carcinoma: the achilles heel of immune checkpoint inhibitors
Z Lin, D Lu, X Wei, J Wang, X Xu - American journal of cancer …, 2020 - ncbi.nlm.nih.gov
Abstract Treatment of patients with hepatocellular carcinoma (HCC) remains a serious
challenge due to high heterogeneity and limited treatment options. In the past few decades …
challenge due to high heterogeneity and limited treatment options. In the past few decades …
Immunologic signatures of peripheral blood T cells reveal the outcome of p53MVA vaccine and pembrolizumab treatment in patients with advanced ovarian cancer
FJ Kos, P Frankel, M Cristea, M Eng, R Tinsley… - Cancer Research …, 2023 - AACR
Purpose: Our previous studies indicated that p53-reactive T cells were associated with
clinical benefit in patients with advanced ovarian cancer who were treated with p53 …
clinical benefit in patients with advanced ovarian cancer who were treated with p53 …
Complete regression of cutaneous metastases with systemic immune response in a patient with triple negative breast cancer receiving p53MVA vaccine with …
Y Yuan, FJ Kos, TF He, HH Yin, M Li, N Hardwick… - …, 2017 - Taylor & Francis
ABSTRACT A heavily pretreated patient with triple negative breast cancer distinguished by
cutaneous metastases received p53MVA vaccine in combination with pembrolizumab. Her …
cutaneous metastases received p53MVA vaccine in combination with pembrolizumab. Her …
Newcastle disease virus-vectored West Nile fever vaccine is immunogenic in mammals and poultry
Abstract Background West Nile virus (WNV) is an emerging zoonotic pathogen which is
harmful to human and animal health. Effective vaccination in susceptible hosts should …
harmful to human and animal health. Effective vaccination in susceptible hosts should …
Vaccination with recombinant modified vaccinia virus A nkara prevents the onset of intestinal allergy in mice
C Bohnen, A Wangorsch, S Schülke… - Allergy, 2013 - Wiley Online Library
Background Modified vaccinia virus A nkara (MVA)‐encoding antigens are considered as
safe vaccine candidates for various infectious diseases in humans. Here, we investigated …
safe vaccine candidates for various infectious diseases in humans. Here, we investigated …