A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous group of
neurological disorders characterized by a progressive, age-dependent decline in neuronal …

Increasing evidence suggests that mitochondrial dysfunction and oxidative stress play a
crucial role in the majority of neurodegenerative diseases. Mitochondria are a major source …

Among age-related neurodegenerative diseases, Parkinson's disease (PD) represents the
best example for which oxidative stress has been strongly implicated. The etiology of PD …

Naturally occurring polyphenols have the potential to prevent oxidative damage in various
pathophysiological conditions. Various members of the flavonoid family were investigated to …

In this study, we examined whether omega‐3 (n‐3) polyunsaturated fatty acids (PUFAs) may
exert neuroprotective action in Parkinson's disease, as previously shown in Alzheimer's …

6-Hydroxydopamine is a neurotoxin commonly used to lesion dopaminergic pathways and
generate experimental models for Parkinson disease, however, the cellular mechanism of 6 …

Astrocyte reactivity is disease‐and stimulus‐dependent, adopting either a proinflammatory
A1 phenotype or a protective, anti‐inflammatory A2 phenotype. Recently, we demonstrated …

Sustained neuroinflammation mediated by resident microglia is recognized as a key
pathophysiological contributor to many neurodegenerative diseases, including Parkinson's …

The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the
accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of …