Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment

PE Goines, P Ashwood - Neurotoxicology and teratology, 2013 - Elsevier
Autism spectrum disorders (ASD) are neurodevelopmental diseases that affect an alarming
number of individuals. The etiological basis of ASD is unclear, and evidence suggests it …

Neurobiological links between depression and AD: the role of TGF-β1 signaling as a new pharmacological target

F Caraci, SF Spampinato, MG Morgese… - Pharmacological …, 2018 - Elsevier
In the last several years a large number of studies have demonstrated the neurobiological
and clinical continuum between depression and Alzheimer's disease (AD). Depression is a …

Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders

N Xu, X Li, Y Zhong - Mediators of inflammation, 2015 - Wiley Online Library
Autism is a disorder of neurobiological origin characterized by problems in communication
and social skills and repetitive behavior. After more than six decades of research, the …

Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat

C Zhang, YP Zhang, YY Li, BP Liu, HY Wang… - Behavioural Brain …, 2019 - Elsevier
Activated microglia-induced neuroinflammation can stimulate the hypothalamic-pituitary-
adrenal (HPA) axis to release glucocorticoids and suppress astrocyte functions, such as …

Astrocytes and the TGF-β1 pathway in the healthy and diseased brain: a double-edged sword

LP Diniz, I Matias, M Siqueira, J Stipursky… - Molecular …, 2019 - Springer
Transforming growth factor betas (TGF-βs) are known as multifunctional growth factors that
participate in the regulation of key events of development, disease, and tissue repair. In the …

Rodent models of depression: neurotrophic and neuroinflammatory biomarkers

M Stepanichev, NN Dygalo, G Grigoryan… - BioMed research …, 2014 - Wiley Online Library
Rodent models are an indispensable tool for studying etiology and progress of depression.
Since interrelated systems of neurotrophic factors and cytokines comprise major regulatory …

Peripheral and central inflammation in autism spectrum disorders

AM Depino - Molecular and Cellular Neuroscience, 2013 - Elsevier
Recent reports have given a central role to environmental factors in the etiology of autism
spectrum disorders (ASD). However, most proposed perinatal factors seem to converge into …

Th17/Treg cells imbalance and their related cytokines (IL-17, IL-10 and TGF-β) in children with autism spectrum disorder

M Moaaz, S Youssry, A Elfatatry… - Journal of …, 2019 - Elsevier
We aimed in this study to investigate a possible involvement of Th17/Treg cells imbalance in
autism spectrum disorders (ASD). Using flowcytometry to determine circulating Th17 and …

Role of neuroinflammation in autism spectrum disorder and the emergence of brain histaminergic system. Lessons also for BPSD?

N Eissa, A Sadeq, A Sasse, B Sadek - Frontiers in pharmacology, 2020 - frontiersin.org
Many behavioral and psychological symptoms of dementia (BPSD) share similarities in
executive functioning and communication deficits with those described in several …

Perinatal stress, brain inflammation and risk of autism-review and proposal

A Angelidou, S Asadi, KD Alysandratos, A Karagkouni… - BMC pediatrics, 2012 - Springer
Abstract Background Autism Spectrum Disorders (ASD) are neurodevelopmental disorders
characterized by varying deficits in social interactions, communication, and learning, as well …