Infection with hepatitis C virus (HCV), which is distributed worldwide, often becomes
persistent, causing chronic hepatitis, cirrhosis, and hepatocellular carcinoma. For many …

Virus-like particles (VLPs) are empty, nanoscale structures morphologically resembling
viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating …

Abstract Background: Hepatitis C virus (HCV) causes acute and chronic human hepatitis
infection and as such is an important global health problem. The virus was discovered in the …

Different variants of hepatitis C virus core protein (HCcAg) have proved to self-assemble in
vitro into virus-like particles (VLPs). However, difficulties in obtaining purified mature HCcAg …

Little is known about the life cycle of hepatitis C virus. Determination of the subcellular
localization of HCV proteins may contribute to our understanding of the in vivo functions of …

Development of heterologous systems to produce useful HCV vaccine candidates is an
important part of HCV research. In this study different HCV structural region variants were …

There have been major advances recently in several areas of hepatitis C virus (HCV). The
array of host receptors important for HCV entry now includes HSGP, LDLR, CD81, SRB1 …

The maturation of the core protein (C) of Hepatitis C virus (HCV) is controlled by the signal
peptidase (sp) and signal peptide peptidase (spp) of the host. To date, it remains unknown …

Little is known about the in vivo assembly pathway or structure of the hepatitis C virus
nucleocapsid. In this work the intermediates of HCcAg multimerization in Pichia pastoris …

Electron microscopy and infrared and Raman spectroscopy have been used here to study
the morphology, size distribution, secondary and tertiary structures of protein particles …