An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

Molnupiravir, an antiviral medication widely used against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), acts by inducing mutations in the virus genome during …

Several human-adapted Mycobacterium tuberculosis complex (Mtbc) lineages exhibit a
restricted geographical distribution globally. These lineages are hypothesized to transmit …

The SARS-CoV-2 genome occupies a unique place in infection biology–it is the most highly
sequenced genome on earth (making up over 20% of public sequencing datasets) with fine …

As observed in cancers, individual mutagens and defects in DNA repair create distinctive
mutational signatures that combine to form context-specific spectra within cells. We …

T492I, a mutation encountered in SARS-CoV-2 nonstructural protein 4 (NSP4), enhances
viral replication and alters nonstructural protein cleavage, causing potential evolutionary …

RNA viruses like SARS-CoV-2 have a high mutation rate, which contributes to their rapid
evolution. The rate of mutations depends on the mutation type (eg, A-to-C, A-to-G, etc.) and …

Pangenomics is an emerging field that uses a collection of genomes of a species instead of
a single reference genome to overcome reference bias and study the within-species genetic …

SARS-CoV-2 genomes collected at the onset of the Covid-19 pandemic are valuable
because they could help understand how the virus entered the human population. In 2021 …

The molecular processes that generate new mutations evolve, but the causal mechanisms
are largely unknown. In particular, the relative rates of mutation types (eg, C> T), the …