A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)
Cannabidiol (CBD) is an abundant non‐psychoactive phytocannabinoid in cannabis
extracts which has high affinity on a series of receptors, including Type 1 cannabinoid …
extracts which has high affinity on a series of receptors, including Type 1 cannabinoid …
Molecular Actions of PPARα in Lipid Metabolism and Inflammation
N Bougarne, B Weyers, SJ Desmet, J Deckers… - Endocrine …, 2018 - academic.oup.com
Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …
Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications
AZ Mirza, II Althagafi, H Shamshad - European journal of medicinal …, 2019 - Elsevier
The peroxisome proliferator-activated receptors (PPAR-α, PPAR-β/δ, and PPAR-γ) are
members of the nuclear receptor super-family, acting as ligand-inducible transcription …
members of the nuclear receptor super-family, acting as ligand-inducible transcription …
PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-β/δ and PPAR-γ
The PPARs are a subfamily of three ligand-inducible transcription factors, which belong to
the superfamily of nuclear hormone receptors. In mammals, the PPAR subfamily consists of …
the superfamily of nuclear hormone receptors. In mammals, the PPAR subfamily consists of …
Rethinking pioglitazone as a cardioprotective agent: a new perspective on an overlooked drug
Since 1985, the thiazolidinedione pioglitazone has been widely used as an insulin
sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early …
sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early …
Molecular and cellular mechanisms of action of cannabidiol
Cannabidiol (CBD) is the primary non-psychoactive chemical from Cannabis Sativa, a plant
used for centuries for both recreational and medicinal purposes. CBD lacks the psychotropic …
used for centuries for both recreational and medicinal purposes. CBD lacks the psychotropic …
Targeting inflammation in metabolic syndrome
FK Welty, A Alfaddagh, TK Elajami - Translational research, 2016 - Elsevier
The metabolic syndrome (MetS) is comprised of a cluster of closely related risk factors,
including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high …
including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high …
Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …
modulated transcription factor that governs the expression of genes involved in …
Calcific aortic valve stenosis: methods, models, and mechanisms
Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The
identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major …
identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major …
The role of various peroxisome proliferator‐activated receptors and their ligands in clinical practice
G Derosa, A Sahebkar, P Maffioli - Journal of Cellular …, 2018 - Wiley Online Library
Peroxisome proliferator‐activated receptors (PPARs) are ligand‐activated transcription
factors involved in several physiological processes including modulation of cellular …
factors involved in several physiological processes including modulation of cellular …