Despite considerable advances, there is a need to improve the outcomes of newborn
infants, especially related to prematurity, encephalopathy and other conditions. In principle …

Right ventricular fibrosis is a stress response, predominantly mediated by cardiac
fibroblasts. This cell population is sensitive to increased levels of pro-inflammatory …

Background. Acute kidney injury (AKI) is one of the common complications of sepsis.
Heretofore, there is no effective treatment for septic AKI. Recent studies have revealed that …

The past 2 decades have witnessed a> 40% improvement in mortality for patients with heart
failure and left ventricular systolic dysfunction. This success has coincided with the stepwise …

Objectives Staged surgical palliation for hypoplastic left heart syndrome results in an
increased workload on the right ventricle serving as the systemic ventricle. Concerns for …

Children with congenital heart diseases have increased morbidity and mortality, despite
various surgical treatments, therefore warranting better treatment strategies. Here we …

Pulmonary arterial hypertension (PAH) remains a deadly disease, and there currently is no
cure for this life-threating medical problem. The average lifespan is about 5 to 7 years after …

Pulmonary arterial hypertension (PAH) is a debilitating multifactorial disease characterized
by progressive pulmonary vascular remodeling, elevated pulmonary arterial pressure, and …

Right ventricular failure (RVF) is a common cause of death in patients suffering from
pulmonary arterial hypertension (PAH). The current treatment for PAH only moderately …

Right ventricular (RV) function is the main determinant of the outcome of patients with
pulmonary hypertension (PH). RV dysfunction develops gradually and worsens …