The serotonin hypothesis of depression is still influential. We aimed to synthesise and
evaluate evidence on whether depression is associated with lowered serotonin …

Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

A recent “umbrella” review examined various biomarkers relating to the serotonin system,
and concluded there was no consistent evidence implicating serotonin in the …

The immune and inflammatory system is involved in the etiology of mood disorders.
Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and …

It has been over 50 years since the original serotonin hypothesis was proposed by the
British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the …

Pleasure and motivation are important factors for goal-directed behavior and well-being in
both animals and humans. Intact hedonic capacity requires an undisturbed interplay …

Neuroimaging, in addition to many other fields of clinical research, is both time-consuming
and expensive, and recruitable patients can be scarce. These constraints limit the possibility …

Background Multiple studies have examined functional and structural brain alteration in
patients diagnosed with major depressive disorder (MDD). The introduction of multivariate …

Introduction Depression, the most prevalent mood disorder, has high comorbidity with
cerebrovascular disease and cognitive decline. However, there is little understanding of the …