Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition
In the tumor microenvironment (TME), communication between cancer cells and tumor-
associated macrophages (TAMs) through secreted extracellular proteins promotes cancer …
associated macrophages (TAMs) through secreted extracellular proteins promotes cancer …
Phosphonate inhibitors of pyruvate dehydrogenase perturb homeostasis of amino acids and protein succinylation in the brain
AV Artiukhov, VA Aleshin, IS Karlina… - International Journal of …, 2022 - mdpi.com
Mitochondrial pyruvate dehydrogenase complex (PDHC) is essential for brain glucose and
neurotransmitter metabolism, which is dysregulated in many pathologies. Using specific …
neurotransmitter metabolism, which is dysregulated in many pathologies. Using specific …
Pyruvate Dehydrogenase-Dependent Metabolic Programming Affects the Oligodendrocyte Maturation and Remyelination
The metabolic needs of the premature/premyelinating oligodendrocytes (pre-OLs) and
mature oligodendrocytes (OLs) are distinct. The metabolic control of oligodendrocyte …
mature oligodendrocytes (OLs) are distinct. The metabolic control of oligodendrocyte …
[HTML][HTML] The downregulation of LINC00273 inhibits the proliferation, invasion, and migration of ovarian cancer cells in vivo and in vitro
C Shu, L Liu, J Xue, J Fei, X Chen, J Wang… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background This study sought to analyze long non-coding ribonucleic acid (lncRNA)
LINC00273 expression in ovarian cancer tissues, and to preliminarily explore its effect on …
LINC00273 expression in ovarian cancer tissues, and to preliminarily explore its effect on …
Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
Insulin is a crucial signalling molecule that primarily functions to reduce blood glucose levels
through cellular uptake of glucose. In addition to its role in glucose homeostasis, insulin has …
through cellular uptake of glucose. In addition to its role in glucose homeostasis, insulin has …
Acylation of the Rat Brain Proteins is Affected by the Inhibition of Pyruvate Dehydrogenase in vivo
VA Aleshin, DA Sibiryakina, AV Kazantsev… - Biochemistry …, 2023 - Springer
Organism adaptation to metabolic challenges requires coupling of metabolism to gene
expression. In this regard, acylations of histones and metabolic proteins acquire significant …
expression. In this regard, acylations of histones and metabolic proteins acquire significant …
Inhibition of pyruvate dehydrogenase affects the brain protein acylation stronger than PDHA phosphorylation at Ser293
VA Aleshin, DA Sibiryakina, AV Kazantsev, AV Graf… - bioRxiv, 2022 - biorxiv.org
Adaptation of an organism to metabolic challenges requires mechanisms coupling
metabolism to gene expression. Acylations of metabolic and histone proteins acquire …
metabolism to gene expression. Acylations of metabolic and histone proteins acquire …
Учредители: Российская академия наук
ВА АЛЕШИН, ДА СИБИРЯКИНА, АВ КАЗАНЦЕВ… - БИОХИМИЯ, 2023 - elibrary.ru
Адаптация организма к нарушениям обмена веществ требует существования
механизмов, связывающих метаболизм с экспрессией генов. В числе таких механизмов …
механизмов, связывающих метаболизм с экспрессией генов. В числе таких механизмов …
[引用][C] Investigating the role of Mitochondrial Derived Peptides (MDPs) in metabolic diseases
AHC Chan - 2024 - ResearchSpace@ Auckland