[HTML][HTML] The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells

PW Andrews, I Barbaric, N Benvenisty, JS Draper… - Cell Stem Cell, 2022 - cell.com
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …

Human induced pluripotent stem cells: from cell origin, genomic stability, and epigenetic memory to translational medicine

MS Poetsch, A Strano, K Guan - Stem Cells, 2022 - academic.oup.com
The potential of human induced pluripotent stem cells (iPSCs) to self-renew indefinitely and
to differentiate virtually into any cell type in unlimited quantities makes them attractive for in …

Genomic instability of iPSCs: challenges towards their clinical applications

M Yoshihara, Y Hayashizaki, Y Murakawa - Stem cell reviews and reports, 2017 - Springer
Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells generated directly
from mature cells through the introduction of key transcription factors. iPSCs can be …

Cellular and engineered organoids for cardiovascular models

D Thomas, S Choi, C Alamana, KK Parker… - Circulation …, 2022 - Am Heart Assoc
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …

Extraordinary performance of semiconducting metal oxide gas sensors using dielectric excitation

RA Potyrailo, S Go, D Sexton, X Li, N Alkadi… - Nature …, 2020 - nature.com
Semiconducting metal oxides are widely used for gas sensors. The resulting chemiresistor
devices, however, suffer from non-linear responses, signal fluctuations and gas cross …

Human induced pluripotent stem cells for modelling neurodevelopmental disorders

K Ardhanareeswaran, J Mariani, G Coppola… - Nature Reviews …, 2017 - nature.com
We currently have a poor understanding of the pathogenesis of neurodevelopmental
disorders, owing to the fact that postmortem and imaging studies can only measure the …

Autologous induced pluripotent stem cell–based cell therapies: Promise, progress, and challenges

M Madrid, C Sumen, S Aivio, N Saklayen - Current protocols, 2021 - Wiley Online Library
The promise of human induced pluripotent stem cells (iPSCs) lies in their ability to serve as
a starting material for autologous, or patient‐specific, stem cell–based therapies. Since the …

iPSC preparation and epigenetic memory: does the tissue origin matter?

G Scesa, R Adami, D Bottai - Cells, 2021 - mdpi.com
The production of induced pluripotent stem cells (iPSCs) represent a breakthrough in
regenerative medicine, providing new opportunities for understanding basic molecular …

Molecular obstacles to clinical translation of iPSCs

N Tapia, HR Schöler - Cell stem cell, 2016 - cell.com
The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) using
defined factors provides new tools for biomedical research. However, some iPSC clones …

Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects

KC Sonntag, B Song, N Lee, JH Jung, Y Cha… - Progress in …, 2018 - Elsevier
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which
affects about 0.3% of the general population. As the population in the developed world ages …