Mechanisms of cell cycle arrest and apoptosis in glioblastoma

K Gousias, T Theocharous, M Simon - Biomedicines, 2022 - mdpi.com
Cells of glioblastoma, the most frequent primary malignant brain tumor, are characterized by
their rapid growth and infiltration of adjacent healthy brain parenchyma, which reflects their …

[HTML][HTML] Enduring neurobiological consequences of early-life stress: Insights from rodent behavioral paradigms

L Speranza, KD Filiz, P Lippiello, MG Ferraro… - Biomedicines, 2024 - mdpi.com
Stress profoundly affects physical and mental health, particularly when experienced early in
life. Early-life stress (ELS) encompasses adverse childhood experiences such as abuse …

Advancing biomedicine with gel‐based materials and composites: A comprehensive review

S Sajjadi, A Gholizadeh‐Hashjin… - Journal of Applied …, 2023 - Wiley Online Library
Polymer gels are an important class of soft materials with growing interest for biomedical
applications due to their distinctive properties. These three‐dimensional polymer networks …

The past, present and future of flow cytometry in central nervous system malignancies

E Vartholomatos, G Vartholomatos, GA Alexiou… - Methods and …, 2021 - mdpi.com
Central nervous system malignancies (CNSMs) are categorized among the most aggressive
and deadly types of cancer. The low median survival in patients with CNSMs is partly …

Sertindole, an antipsychotic drug, curbs the stat3/bcl-xl axis to elicit human bladder cancer cell apoptosis in vitro

CY Hsu, WT Yang, JH Lin, CH Lu, KC Hu… - International Journal of …, 2023 - mdpi.com
Bladder cancer is the leading urinary tract malignancy. Epidemiological evidence has linked
lower cancer incidence in schizophrenia patients to long-term medication, highlighting the …

Repurposing antipsychotics for cancer treatment

N Vlachos, M Lampros, S Voulgaris, GA Alexiou - Biomedicines, 2021 - mdpi.com
Cancer is a leading cause of death worldwide, with approximately 19 million new cases
each year. Lately, several novel chemotherapeutic drugs have been introduced, efficiently …

Drug repurposing: the mechanisms and signaling pathways of anti-cancer effects of anesthetics

KC Wu, KS Liao, LR Yeh, YK Wang - Biomedicines, 2022 - mdpi.com
Cancer is one of the leading causes of death worldwide. There are only limited treatment
strategies that can be applied to treat cancer, including surgical resection, chemotherapy …

An evaluation of the anticancer properties of SYA014, a homopiperazine-oxime analog of haloperidol in triple negative breast cancer cells

GM Asong, C Voshavar, F Amissah, B Bricker… - Cancers, 2022 - mdpi.com
Simple Summary Triple negative breast cancer (TNBC) is one of the most challenging and
hard to treat breast cancer types due to the lack of the receptor targets that are commonly …

Cell cycle dependence on the mevalonate pathway: Role of cholesterol and non-sterol isoprenoids

MA Lasunción, J Martinez-Botas… - Biochemical …, 2022 - Elsevier
The mevalonate pathway is responsible for the synthesis of isoprenoids, including sterols
and other metabolites that are essential for diverse biological functions. Cholesterol, the …

Systematic review of the therapeutic role of apoptotic inhibitors in neurodegeneration and their potential use in schizophrenia

C Morén, N Treder, A Martínez-Pinteño, N Rodríguez… - Antioxidants, 2022 - mdpi.com
Schizophrenia (SZ) is a deleterious brain disorder affecting cognition, emotion and reality
perception. The most widely accepted neurochemical-hypothesis is the imbalance of …