The shared role of cholesterol in neuronal and peripheral inflammation
Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …
[HTML][HTML] Structural insights into the mechanisms and pharmacology of K2P potassium channels
AM Natale, PE Deal, DL Minor Jr - Journal of molecular biology, 2021 - Elsevier
Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …
The role of high cholesterol in age-related COVID19 lethality
Coronavirus disease 2019 (COVID19) is a respiratory infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …
Studies on the mechanism of general anesthesia
MA Pavel, EN Petersen, H Wang… - Proceedings of the …, 2020 - National Acad Sciences
Inhaled anesthetics are a chemically diverse collection of hydrophobic molecules that
robustly activate TWIK-related K+ channels (TREK-1) and reversibly induce loss of …
robustly activate TWIK-related K+ channels (TREK-1) and reversibly induce loss of …
Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture
Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a
treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy. In vitro …
treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy. In vitro …
[HTML][HTML] Disruption of palmitate-mediated localization; a shared pathway of force and anesthetic activation of TREK-1 channels
Abstract TWIK related K+ channel (TREK-1) is a mechano-and anesthetic sensitive channel
that when activated attenuates pain and causes anesthesia. Recently the enzyme …
that when activated attenuates pain and causes anesthesia. Recently the enzyme …
[HTML][HTML] Assessing the potential of repurposing ion channel inhibitors to treat emerging viral diseases and the role of this host factor in virus replication
T Russell, D Gangotia, G Barry - Biomedicine & Pharmacotherapy, 2022 - Elsevier
As diseases caused by new and emerging viruses continue to be a major threat to humans
and animals worldwide the need for new therapeutic options intensifies. A wide variety of …
and animals worldwide the need for new therapeutic options intensifies. A wide variety of …
[HTML][HTML] Hydroxychloroquine: mechanism of action inhibiting SARS-CoV2 entry.
Hydroxychloroquine (HCQ) has been proposed in the treatment of SARS-coronavirus 2
(SARS-CoV-2) infection, albeit with much controversy. In vitro, HCQ effectively inhibits viral …
(SARS-CoV-2) infection, albeit with much controversy. In vitro, HCQ effectively inhibits viral …
Anesthetic Mechanisms: Synergistic Interactions With Lipid Rafts and Voltage-Gated Sodium Channels
WL Krogman, T Woodard, RSF McKay - Anesthesia & Analgesia, 2024 - journals.lww.com
Despite successfully utilizing anesthetics for over 150 years, the mechanism of action
remains relatively unknown. Recent studies have shown promising results, but due to the …
remains relatively unknown. Recent studies have shown promising results, but due to the …
N-Glycosylation of TREK-1/hK2P2.1 Two-Pore-Domain Potassium (K2P) Channels
F Wiedmann, D Schlund, F Faustino, M Kraft… - International Journal of …, 2019 - mdpi.com
Mechanosensitive hTREK-1 two-pore-domain potassium (hK2P2. 1) channels give rise to
background currents that control cellular excitability. Recently, TREK-1 currents have been …
background currents that control cellular excitability. Recently, TREK-1 currents have been …