GDF15 as a key disease target and biomarker: Linking chronic lung diseases and ageing

Y Wan, J Fu - Molecular and cellular biochemistry, 2024 - Springer
Abstract Growth differentiation factor 15 (GDF15), a member of the transforming growth
factor-beta superfamily, is expressed in several human organs. In particular, it is highly …

Organokines in COVID-19: a systematic review

SM Barbalho, G Minniti, VFB Miola, JFS Haber… - Cells, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19) is a viral infection caused by SARS-CoV-2 that
induces a generalized inflammatory state. Organokines (adipokines, osteokines, myokines …

Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: A Position Paper from the ESC Working Group on Thrombosis, in …

DA Gorog, YX Gue, TF Chao, L Fauchier, JL Ferreiro… - Europace, 2022 - academic.oup.com
Whilst there is a clear clinical benefit of oral anticoagulation (OAC) in patients with atrial
fibrillation (AF) and venous thromboembolism (VTE) in reducing the risks of …

Biomarkers associated with cardiovascular disease in COVID-19

CC Kaufmann, A Ahmed, AL Burger, M Muthspiel… - Cells, 2022 - mdpi.com
Coronavirus disease-19 (COVID-19) emerged late December 2019 in the city of Wuhan,
China and has since spread rapidly all over the world causing a global pandemic. While the …

Emerging roles of growth differentiation factor 15 in immunoregulation and pathogenesis

J Reyes, GS Yap - The Journal of Immunology, 2023 - journals.aai.org
Abstract Growth differentiation factor 15 (GDF-15) is a cytokine that is widely used as a
biomarker for the severity of diverse disease states. It also has been shown to play a …

Cardiac biomarkers and their role in identifying increased risk of cardiovascular complications in COVID-19 patients

N Yaluri, A Stančáková Yaluri, P Žeňuch, Z Žeňuchová… - Diagnostics, 2023 - mdpi.com
Cardiovascular disease (CVD) is a global health concern, causing significant morbidity and
mortality. Both lifestyle and genetics influence the development of CVD. It is often diagnosed …

Proteomics validate circulating GDF-15 as an independent biomarker for COVID-19 severity

S Bu, L Royston, T Mabanga, CA Berini… - Frontiers in …, 2024 - frontiersin.org
Introduction Growth differentiation factor 15 (GDF-15) was originally described as a stress-
induced cytokine, and a biomarker of aging and cardiovascular diseases. We hypothesized …

A real Pandora's box in pandemic times: a narrative review on the acute cardiac injury due to COVID-19

AS Timpau, RS Miftode, D Leca, R Timpau, IL Miftode… - Life, 2022 - mdpi.com
The intricate relationship between severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) and the cardiovascular system is an extensively studied pandemic topic, as there is …

The cytokine growth differentiation factor-15 and skeletal muscle health: portrait of an emerging widely applicable disease biomarker

B De Paepe - International Journal of Molecular Sciences, 2022 - mdpi.com
Growth differentiation factor 15 (GDF-15) is a stress-induced transforming growth factor-β
superfamily cytokine with versatile functions in human health. Elevated GDF-15 blood levels …

Growth differentiation factor-15 is an IFN-γ regulated mediator of infection-induced weight loss and the hepatic FGF21 response

J Reyes, Y Zhao, K Pandya, GS Yap - Brain, Behavior, and Immunity, 2024 - Elsevier
Infections are often accompanied by weight loss caused by alterations in host behavior and
metabolism, also known as sickness behaviors. Recent studies have revealed that sickness …