Anthracyclines are used in over 50% of childhood cancer treatment protocols, but their
clinical usefulness is limited by anthracycline-induced cardiotoxicity (ACT) manifesting as …

Purpose Anthracycline-induced cardiotoxicity (ACT) is a serious adverse drug reaction
limiting anthracycline use and causing substantial morbidity and mortality. Our aim was to …

Cisplatin is a widely used and effective chemotherapeutic agent, although its use is
restricted by the high incidence of irreversible ototoxicity associated with it. In children …

Background. The use of anthracyclines as effective antineoplastic drugs is limited by the
occurrence of cardiotoxicity. Multiple genetic variants predictive of anthracycline‐induced …

Aim: To identify novel variants associated with anthracycline-induced cardiotoxicity and to
assess these in a genotype-guided risk prediction model. Patients & methods: Two cohorts …

The occurrence of hypersensitivity reactions including rare but life‐threatening Stevens–
Johnson syndrome (SJS) and drug‐induced hypersensitivity syndrome (HSS) limits the use …

Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors. A
serious complication of cisplatin treatment is permanent hearing loss. The aim of this study …

Multiple sclerosis (MS) is a chronic, progressive, disabling disorder characterized by
immune-mediated demyelination, inflammation, and neurodegenerative tissue damage in …

Recent studies have pointed out the essential role of genetic ancestry in population
pharmacogenetics. In this study, we analyzed the whole-genome sequencing data from The …

Interethnic variability in drug response arises from genetic differences associated with drug
metabolism, action and transport. These genetic variations can affect drug efficacy as well as …