Highlights•Nogo-A limits neural repair and recovery after adult CNS injuries.•NgR1 and
S1PR2 are receptors for different domains of Nogo-A.•Nogo-A and NgR1 limit experience …

Neuronal plasticity in the brain is greatly enhanced during critical periods early in life and
was long thought to be rather limited thereafter. Studies in primary sensory areas of the …

RTN4-binding proteins were widely studied as" NoGo" receptors, but their physiological
interactors and roles remain elusive. Similarly, BAI adhesion-GPCRs were associated with …

In many regions of the developing brain, neuronal circuits undergo defined phases of
enhanced plasticity, termed critical periods. Work in the rodent visual cortex has led to …

Nogo-A is a membrane protein of the central nervous system (CNS) restricting neurite
growth and synaptic plasticity via two extracellular domains: Nogo-66 and Nogo-A-Δ20 …

Antibody delivery to the CNS remains a huge hurdle for the clinical application of antibodies
targeting a CNS antigen. The blood–brain barrier and blood–CSF barrier restrict access of …

Axonal damage leads to permanent deficits in the adult central nervous system (CNS) not
only because of the weak intrinsic ability of adult neurons to activate their growth program …

The storage of information in the mammalian nervous systems is dependent on a delicate
balance between change and stability of neuronal networks. The induction and …

Myelin sheaths in the central nervous system (CNS) insulate axons and thereby allow
saltatory nerve conduction, which is a prerequisite for complex brain function. Multiple …

Brain ischemia affects all ages, from neonates to the elderly population, and is a leading
cause of mortality and morbidity. Multiple preclinical rodent models involving different ages …