The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …

There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

Guanosine is a purine nucleoside with important functions in cell metabolism and a
protective role in response to degenerative diseases or injury. The past decade has seen …

Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released
in the brain under physiological conditions and even more during pathological events …

The function of guanine-based purines (GBPs) is mostly attributed to the intracellular
modulation of heteromeric and monomeric G proteins. However, extracellular effects of …

Guanosine, a guanine-based purine, is an extracellular signaling molecule that is released
from astrocytes and has been shown to promote central nervous system defenses in several …

Chronic cerebral hypoperfusion (CCH) has been considered as a critical cause for the
development of cognitive decline and dementia of vascular origin. Melatonin receptors have …

Neurodegenerative diseases and brain tumours represent important health challenges due
to their severe nature and debilitating consequences that require substantial medical care …

Guanosine, a guanine‐based purine, is an extracellular signaling molecule that is released
from astrocytes and shows neuroprotective effects in several in vivo and in vitro studies. Our …

Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted
patients. Despite advances in the understanding of MDD and its treatment, profound …