Pot economy and one-pot synthesis

Y Hayashi - Chemical science, 2016 - pubs.rsc.org
The one-pot synthesis of a target molecule in the same reaction vessel is widely considered
to be an efficient approach in synthetic organic chemistry. In this review, the characteristics …

Time and pot economy in total synthesis

Y Hayashi - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus We would all like to make or obtain the materials or products we want as soon
as possible. This is human nature. This is true also for chemists in the synthesis of organic …

Time economy in total synthesis

Y Hayashi - The Journal of Organic Chemistry, 2020 - ACS Publications
It is often said that “time is money”. This is certainly true in a multistep synthesis when a high-
valued product or set of products is needed urgently. Fulfilling this need requires the …

Synthesis and medical applications of oligosaccharides

PH Seeberger, DB Werz - Nature, 2007 - nature.com
Our understanding of the different glycoconjugates present on cells, proteins and entire
organisms is lagging far behind advances in genomics and proteomics. Carbohydrate …

Recent advances of iridium (III) metallophosphors for health-related applications

PY Ho, CL Ho, WY Wong - Coordination Chemistry Reviews, 2020 - Elsevier
Phosphorescent transition metal complexes have been intensively investigated, since these
luminophores are distinctively different from fluorescent chromophores in terms of the nature …

High‐yielding synthesis of the anti‐influenza neuramidase inhibitor (−)‐oseltamivir by three “one‐pot” operations

H Ishikawa, T Suzuki, Y Hayashi - Angewandte Chemie, 2009 - Wiley Online Library
A great deal of attention has been paid both in the scientific literature and the general media
to the high potential risk of a worldwide spread of avian H5N1 influenza virus, the death rate …

Asymmetric organocatalysis in total synthesis–a trial by fire

E Marqués-López, RP Herrera… - Natural Product …, 2010 - pubs.rsc.org
Covering: 2007 to 2009 This review covers the most recent applications of organocatalysis
in the synthesis of natural products and non-natural biologically active molecules. Our aim is …

The new era of drug discovery: The power of computer-aided drug design (CADD)

IJS Nascimento, TM de Aquino… - Letters in Drug …, 2022 - ingentaconnect.com
Drug design and discovery is a process that requires high financial costs and is
timeconsuming. For many years, this process focused on empirical pharmacology. However …

Production of shikimic acid

S Ghosh, Y Chisti, UC Banerjee - Biotechnology advances, 2012 - Elsevier
Shikimic acid is a key intermediate for the synthesis of the antiviral drug oseltamivir
(Tamiflu®). Shikimic acid can be produced via chemical synthesis, microbial fermentation …

Underexplored opportunities for natural products in drug discovery: miniperspective

BL DeCorte - Journal of Medicinal Chemistry, 2016 - ACS Publications
The importance of natural products in the treatment of human disease is well documented.
While natural products continue to have a profound impact on human health, chemists have …