No other tissue in the body depends more on the composition and organization of the
extracellular matrix (ECM) for normal structure and function than the corneal stroma. The …

After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

The adult zebrafish heart has a high capacity for regeneration following injury. However, the
composition of the regenerative niche has remained largely elusive. Here, we dissected the …

Spinal cord injury leads to a massive response of innate immune cells in non-regenerating
mammals, but also in successfully regenerating zebrafish. However, the role of the immune …

Unlike adult mammals, zebrafish regenerate spinal cord tissue and recover locomotor ability
after a paralyzing injury. Here, we find that ependymal cells in zebrafish spinal cords …

Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

Age-related macular degeneration (AMD) is a progressive, degenerative disease of the
human retina which in its most aggressive form is associated with the formation of macular …

The mechanical properties of biological tissues are increasingly recognized as important
factors in developmental and pathological processes. Most existing mechanical …

Spinal cord injury (SCI) leads to fibrotic scar formation at the lesion site, yet the
heterogeneity of fibrotic scar remains elusive. Here we show the heterogeneity in …

Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure,
and treatment options to promote neural recovery are limited. An innovative approach to …