The mammalian skeletal system is densely innervated by both neural and vascular
networks. Peripheral nerves in the skeleton include sensory and sympathetic nerves. The …

Space is an extreme environment for the human body, where during long-term missions
microgravity and high radiation levels represent major threats to crew health. Intriguingly …

Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

The importance of the vascular supply for bone is well-known to orthopaedists but is still
rather overlooked within the wider field of skeletal research. Blood supplies oxygen …

We have examined the regulation of lipoprotein lipase (LPL) activity in skeletal muscle
during physical inactivity in comparison to low‐intensity contractile activity of ambulatory …

Bone is a highly vascularized tissue, although this aspect of bone is often overlooked. In this
article, the importance of blood flow in bone repair and regeneration will be reviewed. First …

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has generated great interest in
the medical and research communities yet remains an enigma, given its unknown …

The rodent hindlimb unloading (HU) model was developed in the 1980s to make it possible
to study mechanisms, responses, and treatments for the adverse consequences of …

Systematic study of bones' responses to loading requires simple non-invasive models in
appropriate experimental animals where the applied load is controllable and the changes in …

Skeletal muscle disuse with space-flight and ground-based models (eg, hindlimb unloading)
results in dramatic skeletal muscle atrophy and weakness. Pathological conditions that …