Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

Hyaluronic acid (HA) is widely used in anticancer drug delivery, since it is biocompatible,
biodegradable, non-toxic, and non-immunogenic; moreover, HA receptors are …

Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …

Hyaluronic acid (HA) is a linear polysaccharide and crucial component of the extracellular
matrix (ECM), maintaining tissue hydration and tension. Moreover, HA contributes to …

Hyaluronan (HA) is a major glycosaminoglycan in the extracellular matrix whose expression
is tightly linked to multidrug resistance and tumor progression. In this study we investigated …

Multidrug resistance and disease relapse is a challenging clinical problem in the treatment
of breast cancer. In this study, we investigated the hyaluronan (HA)-induced interaction …

Microenvironment plays a crucial role in tumor development and progression. Cancer cells
modulate the tumor microenvironment, which also contribute to resistance to therapy …

Multidrug resistance (MDR) of cancer tissue is a phenomenon in which cancer cells exhibit
reduced sensitivity to a large group of unrelated drugs with different mechanisms of …

Hyaluronic acid or hyaluronan (HA) is perhaps one of the most uncomplicated large
polymers that regulates several normal physiological processes and, at the same time …

Hyaluronan not only is an important structural component of extracellular matrices but also
interacts instructively with cells during embryonic development, healing processes …