Allergic diseases are on the rise in the Western world and well-known allergy-protecting and-
driving factors such as microbial and dietary exposure, pollution and smoking mediate their …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa.
Environmental factors, genetics, intestinal microbiota, and the immune system are all …

Epigenetics contributes to the pathogenesis of immune-mediated diseases like rheumatoid
arthritis (RA). Here we show the first comprehensive epigenomic characterization of RA …

Stratifying patients on the basis of molecular signatures could facilitate development of
therapeutics that target pathways specific to a particular disease or tissue location. Previous …

Autoimmune diseases are chronic inflammatory disorders caused by a loss of self‐
tolerance, which is characterized by the appearance of autoantibodies and/or autoreactive …

Genome-wide association studies have revealed several genes predisposing to
autoimmunity, however, concordance rates in monozygotic twins are significantly below …

Objective Determine whether MS-specific DNA methylation profiles can be identified in
whole blood or purified immune cells from untreated MS patients. Methods Whole blood …

Background Beyond genetics, epigenetics alterations and especially those related to DNA
methylation, play key roles in the pathogenesis of autoimmune diseases such as primary …

The number of people diagnosed with chronic inflammatory diseases has increased
noteworthy in the last 40 years. Spondyloarthritis (SpA), inflammatory bowel diseases (IBD) …

Pemphigus is a group of autoimmune bullous skin diseases that result in significant
morbidity. As for other multifactorial autoimmune disorders, environmental factors may …