Genetic Regulation of Virulence and Antibiotic Resistance in Acinetobacter baumannii

C Kröger, SC Kary, K Schauer, ADS Cameron - Genes, 2016 - mdpi.com
Multidrug resistant microorganisms are forecast to become the single biggest challenge to
medical care in the 21st century. Over the last decades, members of the genus …

The functional RNA cargo of bacterial membrane vesicles

P Dauros-Singorenko, C Blenkiron… - FEMS microbiology …, 2018 - academic.oup.com
Bacteria secrete RNAs, some of which have effects on other cells and on other species as
signalling RNAs. Prokaryotic membrane vesicles (MVs) contain a range of RNA types. The …

Evidence for Rho-dependent control of a virulence switch in Acinetobacter baumannii

M Pérez-Varela, R Singh, JM Colquhoun, OG Starich… - Mbio, 2024 - Am Soc Microbiol
Acinetobacter baumannii strain AB5075 is able to interconvert at high frequency between
virulent cells that form opaque colonies (VIR-O) and avirulent cells that form translucent …

The primary transcriptome, small RNAs and regulation of antimicrobial resistance in Acinetobacter baumannii ATCC 17978

C Kröger, KD MacKenzie, EY Alshabib… - Nucleic acids …, 2018 - academic.oup.com
We present the first high-resolution determination of transcriptome architecture in the priority
pathogen Acinetobacter baumannii. Pooled RNA from 16 laboratory conditions was used for …

Rapidly moving new bacteria to model-organism status

H Liu, AM Deutschbauer - Current opinion in biotechnology, 2018 - Elsevier
Highlights•Global annotation of gene function in bacteria from mutant fitness.•Genome-wide
interrogation of bacterial essential genes using CRISPR interference.•Microfluidic approach …

Global analysis of the RNA–RNA interactome in Acinetobacter baumannii AB5075 uncovers a small regulatory RNA repressing the virulence-related outer membrane …

FJ Hamrock, D Ryan, A Shaibah… - Nucleic Acids …, 2024 - academic.oup.com
Acinetobacter baumannii is an opportunistic Gram-negative pathogen that infects critically ill
patients. The emergence of antimicrobial resistant A. baumannii has exacerbated the need …

The ω subunit governs RNA polymerase stability and transcriptional specificity in Staphylococcus aureus

A Weiss, BD Moore, MHJ Tremblay… - Journal of …, 2017 - Am Soc Microbiol
Staphylococcus aureus is a major human pathogen that causes infection in a wide variety of
sites within the human body. Its ability to adapt to the human host and to produce a …

The Acinetobacter baumannii model can explain the role of small non-coding RNAs as potential mediators of host-pathogen interactions

M Sarshar, D Scribano, AT Palamara… - Frontiers in Molecular …, 2022 - frontiersin.org
Bacterial small RNAs (sRNAs) research has accelerated over the past decade, boosted by
advances in RNA-seq technologies and methodologies for capturing both protein–RNA and …

CsrA-controlled proteins reveal new dimensions of Acinetobacter baumannii desiccation tolerance

Y Oda, MM Shapiro, NM Lewis, X Zhong… - Journal of …, 2022 - Am Soc Microbiol
Hospital environments are excellent reservoirs for the opportunistic pathogen Acinetobacter
baumannii in part because it is exceptionally tolerant to desiccation. We found that relative to …

'GGFGGQ'repeats in Hfq of Acinetobacter baumannii are essential for nutrient utilization and virulence

A Sett, PK Maiti, K Garg, A Hussain, S Saini… - Journal of Biological …, 2024 - jbc.org
The nosocomial pathogen Acinetobacter baumannii is known for causing lung and soft
tissue infections in immunocompromised hosts. Its ability to adapt to various environments …