Neuroprotective role of coconut oil for the prevention and treatment of Parkinson's disease: Potential mechanisms of action

D N. P, MS Kondengadan, SH Sweilam… - Biotechnology and …, 2024 - Taylor & Francis
Neurodegenerative disease (ND) is a clinical condition in which neurons degenerate with a
consequent loss of functions in the affected brain region. Parkinson's disease (PD) is the …

[PDF][PDF] Finding vitamin Ex

JM Zingg - Free Radical Biology and Medicine, 2024 - Elsevier
At this time, it is generally accepted that only RRR-α-tocopherol (αT) harbours all the
essential activities required for the proper functioning of metabolism in the body and thus …

[HTML][HTML] The Impact of LPS on Inflammatory Responses in Alpha-Tocopherol Deficient Mice

MH Seese, AJ Steelman, JW Erdman Jr - Current Developments in Nutrition, 2024 - Elsevier
Background To facilitate the evaluation of vitamin E (α-tocopherol, αT) status on health
outcomes, the αT transfer protein knockout (Ttpa–/–) mouse model has proved to be an …

α-Tocopherol Depletion Exacerbates Lipopolysaccharide-Induced Reduction of Grip Strength

M Hashida, AJ Steelman, JW Erdman Jr - The Journal of Nutrition, 2024 - Elsevier
Background α-Tocopherol (αT) deficiency causes several neurologic disorders, such as
spinocerebellar ataxia, peripheral neuropathy, and myopathy. Furthermore, decreased …

[HTML][HTML] α-Tocopherol transfer protein-null mice with very low α-tocopherol status do not have an enhanced lipopolysaccharide-induced acute inflammatory response

M Hashida, KM Ranard, AJ Steelman… - Current Developments in …, 2023 - Elsevier
Background The α-tocopherol transfer protein-null (Ttpa−/−) mouse model is a valuable tool
for studying the molecular and functional consequences of vitamin E (α-tocopherol, αT) …

合成ビタミンE 摂取によるビタミンE 立体異性体の脳への移行

池田彩子, 小林美里, 阪野朋子 - ビタミン, 2021 - jstage.jst.go.jp
比較したときの相対値 (%) RRR-α-トコフェロール 1.49 100 RRS-α-トコフェロール 1.34 90 RSR-α-
トコフェロール 0.85 57 RSS-α-トコフェロール 1.09 73 SRR-α-トコフェロール 0.46 31 SRS-α …

ビタミンE の長鎖代謝物であるガルシン酸は核内受容体pregnane X receptor のアゴニストとして機能する

藤井晋也 - ビタミン, 2022 - jstage.jst.go.jp
フォメーションが PXR との結合に重要であることから, 側鎖の立体異性体の間で PXR
リガンド活性が異なる可能性も考えられる. T の天然体 (2R, 4'R, 8'R) と合成品 …