Crosstalk between bone and nerves within bone

QQ Wan, WP Qin, YX Ma, MJ Shen, J Li… - Advanced …, 2021 - Wiley Online Library
For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

Endocrine role of bone in the regulation of energy metabolism

R Zhou, Q Guo, Y Xiao, Q Guo, Y Huang, C Li, X Luo - Bone research, 2021 - nature.com
Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

Nerves in bone: evolving concepts in pain and anabolism

JM Brazill, AT Beeve, CS Craft… - Journal of Bone and …, 2019 - academic.oup.com
The innervation of bone has been described for centuries, and our understanding of its
function has rapidly evolved over the past several decades to encompass roles of subtype …

[HTML][HTML] Sympathetic neuropeptide Y protects from obesity by sustaining thermogenic fat

Y Zhu, L Yao, AL Gallo-Ferraz, B Bombassaro… - Nature, 2024 - nature.com
Human mutations in neuropeptide Y (NPY) have been linked to high body mass index but
not altered dietary patterns. Here we uncover the mechanism by which NPY in sympathetic …

Inhibition of CGRP signaling impairs fracture healing in mice

NKY Wee, S Novak, D Ghosh, SH Root… - Journal of …, 2023 - Wiley Online Library
Calcitonin gene‐related peptide (CGRP) is a neuropeptide produced by sensory nerves and
functions as a pain sensor. It acts by binding to the calcitonin‐like receptor (CLR, protein; …

Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice

R Kumari, R Pascalau, H Wang, S Bajpayi, M Yurgel… - Cell reports, 2024 - cell.com
Neuropeptide Y (NPY) is best known for its effects in the brain as an orexigenic and
anxiolytic agent and in reducing energy expenditure. NPY is also co-expressed with …

Engraftment of skeletal progenitor cells by bone-directed transplantation improves osteogenesis imperfecta murine bone phenotype

BP Sinder, S Novak, NKY Wee, M Basile, P Maye… - Stem Cells, 2020 - academic.oup.com
Osteogenesis imperfecta (OI) is a genetic disorder most commonly caused by mutations
associated with type I collagen, resulting in a defective collagen bone matrix. Current …

Skeletal stem cells: origins, definitions, and functions in bone development and disease

H Feng, B Jiang, W Xing, J Sun, MB Greenblatt… - Life …, 2022 - academic.oup.com
Skeletal stem cells (SSCs) are tissue-specific stem cells that can self-renew and sit at the
apex of their differentiation hierarchy, giving rise to mature skeletal cell types required for …

[HTML][HTML] Mechanisms of action of neuropeptide Y on stem cells and its potential applications in orthopaedic disorders

JQ Wu, N Jiang, B Yu - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
Musculoskeletal disorders are the leading causes of disability and result in reduced quality
of life. The neuro-osteogenic network is one of the most promising fields in orthopaedic …

Neuropeptide Y acts directly on cartilage homeostasis and exacerbates progression of osteoarthritis through NPY2R

X Kang, Z Qian, J Liu, D Feng, H Li… - Journal of Bone and …, 2020 - academic.oup.com
Neuropeptide Y (NPY) is known to regulate bone homeostasis; however, its functional role
as a risk factor during osteoarthritis (OA) remains elusive. In this study, we aim to investigate …