Primary cilia are specialized sensory organelles that protrude from the apical surface of most
cell types. Over the past two decades, they have been found to play important roles in tissue …

The Piezo channel family, including Piezo1 and Piezo2, includes essential
mechanosensitive transduction molecules in mammals. Functioning in the conversion of …

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis
and resilience. Emerging evidence has demonstrated age-associated changes in circadian …

Mammalian organs exhibit distinct physiology, disease susceptibility, and injury responses
between the sexes. In the mouse kidney, sexually dimorphic gene activity maps …

When the filtrate of the glomerulus flows through the renal tubular system, various
microscopic sediment particles, including mineral crystals, are generated. Dislodging these …

The primary cilium projects from the surface of most vertebrate cells, where it senses
extracellular signals to regulate diverse cellular processes during tissue development and …

Simple Summary Electrolyte balance is very significant, ensures homeostasis of the
organism, maintains reactions, nerve conduction, and proper polarity of cell membranes …

Many different strategies can be found in the literature to model organ physiology, tissue
functionality, and disease in vitro; however, most of these models lack the physiological fluid …

Measurement of cell metabolism in moderate-throughput to high-throughput organ-on-chip
(OOC) systems would expand the range of data collected for studying drug effects or …

Glutaric aciduria type I (GA-I, OMIM# 231670) is an autosomal recessive inborn error of
metabolism caused by deficiency of the mitochondrial enzyme glutaryl-CoA dehydrogenase …