Toxoplasma gondii is a protozoan parasite of global importance. In the laboratory setting, T.
gondii is frequently used as a model pathogen to study mechanisms of T helper 1 (TH1) cell …

Toxoplasma gondii is a protozoan parasite of medical and veterinary significance that is
able to infect any warm-blooded vertebrate host. In addition to its importance to public …

Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …

Phagocytosis provides innate immune cells with a mechanism to take up and destroy
pathogenic bacteria, apoptotic cells and other large particles. In some cases, however …

Antigen (Ag) crosspresentation by dendritic cells (DCs) involves the presentation of
internalized Ags on MHC class I molecules to initiate CD8+ T cell-mediated immunity in …

The unfolded protein response (UPR) is a cytoprotective response that is aimed at restoring
cellular homeostasis following physiological stress exerted on the endoplasmic reticulum …

Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I
molecules with endogenous peptides during their biosynthesis within the endoplasmic …

To monitor the health of cells, the immune system tasks antigen-presenting cells with
gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides …

The induction of most CD8+ T cell responses by dendritic cells (DCs) requires the
presentation of peptides from internalized antigen by class I MHC molecules. Increasing …

Dendritic cells (DCs) present foreign antigen in major histocompatibility complex (MHC)
class I molecules to cytotoxic T cells in a process called cross-presentation. An important …