Metformin is among the most widely used antidiabetic drugs. Studies over the past few years
have identified multiple novel molecular targets and pathways that metformin acts on to exert …

Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2. Elderly
people, people with immunodeficiency, autoimmune and malignant diseases, as well as …

Nutrient digestion, absorption, and export must be coordinated in the gut to meet the
nutritional needs of the organism. We used the Drosophila intestine to characterize the …

Cardiogenic growth factors play important roles in heart development. Placental growth
factor (PLGF) has previously been reported to have angiogenic effects; however, its potential …

The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this
study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for …

Obesity-related metabolic dysfunction, endothelium imbalance, chronic inflammation,
immune dysregulation, and its comorbidities may all have a role in systemic inflammation …

Background & Aims The intestinal epithelium intrinsically renews itself ex vivo via the
proliferation of Lgr5+ intestinal stem cells, which is sustained by the establishment of an …

In sheep, body weight is an economically important trait. This study sought to map genetic
loci related to weaning weight and yearling weight. To this end, a single-trait and multi-trait …

The gut microbiota is closely linked to atherosclerosis. However, the role of intestinal fungi,
essential members of the complex microbial community, in atherosclerosis is poorly …

Background & Aims The intestine constantly interprets and adapts to complex combinations
of dietary and microbial stimuli. However, the transcriptional strategies by which the …