Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …

In human vascular anatomy, blood flows from the heart to organs and tissues through a
hierarchical vascular tree, comprising large arteries that branch into arterioles and further …

Despite the efforts devoted to drug discovery and development, the number of new drug
approvals have been decreasing. Specifically, cardiovascular developments have been …

Smooth muscle cell (SMC) diversity and plasticity are limiting factors in their characterization
and application in cardiovascular tissue engineering. This work aimed to evaluate the …

Endogenous electrically mediated signaling is a key feature of most native tissues, the most
notable examples being the nervous and the cardiac systems. Biomedical engineering often …

Early reports have demonstrated the feasibility of oxidized dextran/gelatin (OD/GEL)
hydrogel for tissue engineering applications and the printability of OD/GEL hydrogel for 3D …

Spheroid formation with spontaneous aggregation has captured interest in most cell culture
studies due to its easy set-up and more reliable results. However, the economic and …

The microarchitecture of bone tissue engineering (BTE) scaffolds has been shown to have a
direct effect on the osteogenesis of mesenchymal stem cells (MSCs) and bone tissue …

Tissue-engineered human blood vessels may enable in vitro disease modeling and drug
screening to accelerate advances in vascular medicine. Existing methods for tissue …

Background Skeletal muscle wound healing is dependent on complex interactions between
fibroblasts, myofibroblasts, myogenic cells, and cytokines, such as TGF-β1. This study …