Human γδ TCR repertoires in health and disease
The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells.
While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the …
While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the …
Role of γδ T cells in controlling viral infections with a focus on influenza virus: implications for designing novel therapeutic approaches
Background Influenza virus infection is among the most detrimental threats to the health of
humans and some animals, infecting millions of people annually all around the world and in …
humans and some animals, infecting millions of people annually all around the world and in …
Longitudinal outcomes for multisystem inflammatory syndrome in children
BACKGROUND In spring 2020, a novel hyperinflammatory process associated with severe
acute respiratory syndrome coronavirus 2 multisystem inflammatory syndrome in children …
acute respiratory syndrome coronavirus 2 multisystem inflammatory syndrome in children …
MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals
Despite the high number of individuals infected by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) symptoms …
coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) symptoms …
γδ T cell exhaustion: Opportunities for intervention
D Chen, Y Guo, J Jiang, P Wu, T Zhang… - Journal of Leukocyte …, 2022 - academic.oup.com
T lymphocytes are the key protective contributors in chronic infection and tumor, but
experience exhaustion by persistent antigen stimulation. As an unconventional lineage of T …
experience exhaustion by persistent antigen stimulation. As an unconventional lineage of T …
Animal Models of Cryptococcus neoformans in Identifying Immune Parameters Associated With Primary Infection and Reactivation of Latent Infection
TG Normile, AM Bryan, M Del Poeta - Frontiers in Immunology, 2020 - frontiersin.org
Cryptococcus species are environmental fungal pathogens and the causative agents of
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …
Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderly humans (over 75 years) and aged mice
Objective Aging induces several physiologic and immune changes. The usefulness of
probiotics in ameliorating age-related disorders remains largely unexplored. The aim of this …
probiotics in ameliorating age-related disorders remains largely unexplored. The aim of this …
Human and murine memory γδ T cells: Evidence for acquired immune memory in bacterial and viral infections and autoimmunity
K Comeau, P Paradis, EL Schiffrin - Cellular Immunology, 2020 - Elsevier
Abstract γδ T cells are unconventional lymphocytes that could play a role in bridging the
innate and adaptive immune system. Upon initial exposure to an antigen, some activated T …
innate and adaptive immune system. Upon initial exposure to an antigen, some activated T …
Host-directed therapy as a novel treatment strategy to overcome tuberculosis: targeting immune modulation
Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in
developing countries, presenting a major threat to the public health. The currently …
developing countries, presenting a major threat to the public health. The currently …
A Cell for the Ages: Human γδ T Cells across the Lifespan
BL Clark, PG Thomas - International journal of molecular sciences, 2020 - mdpi.com
The complexity of the human immune system is exacerbated by age-related changes to
immune cell functionality. Many of these age-related effects remain undescribed or driven by …
immune cell functionality. Many of these age-related effects remain undescribed or driven by …