Within the ovarian cancer tumor microenvironment, cancer stem-like cells (CSC) interact with carcinoma associated mesenchymal stem/stromal cells (CA-MSC) through multiple …
Cancer treatment development is a complex process, with tumor heterogeneity and inter- patient variations limiting the success of therapeutic intervention. Traditional two …
MN Brodeur, K Simeone, K Leclerc-Deslauniers… - Scientific reports, 2021 - nature.com
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Among the key challenges in developing effective therapeutics is the poor translation of preclinical models …
A Kapur, P Mehta, AD Simmons, SS Ericksen, G Mehta… - Cancers, 2022 - mdpi.com
Simple Summary The Warburg effect in cancer cells (high glucose update and lactate release) is an adaptation that is considered a hallmark of most neoplasms. Blocking …
EN Horst, CM Novak, K Burkhard, CS Snyder, R Verma… - Acta biomaterialia, 2022 - Elsevier
Epithelial ovarian cancers are among the most aggressive forms of gynecological malignancies. Despite the advent of poly adenosine diphosphate-ribose polymerase …
CS Snyder, T Repetto, KM Burkhard, A Tuteja… - Cancer Stem Cells …, 2024 - Springer
Nanoparticle drug delivery has been promoted as an effective mode of delivering antineoplastic therapeutics. However, most nanoparticle designs fail to consider the …
M Bregenzer, E Horst, P Mehta, C Snyder… - … Cancer: Methods and …, 2022 - Springer
Cancer stem-like cells (CSC) are responsible for tumor progression, chemoresistance, recurrence, and poor outcomes in many cancers, making them critical research and …
M Boban, P Mehta, AK Halvey, T Repetto… - Analytical …, 2021 - ACS Publications
Multicellular spheroids are superior to other culture geometries in reproducing critical physiological conditions of tumors, such as the diffusion of oxygen, nutrients, waste, and …
HY Chu, YJ Chen, CJ Hsu, YW Liu, JF Chiou, LS Lu… - Cancers, 2020 - mdpi.com
Tissue-specific microenvironmental factors contribute to the targeting preferences of metastatic cancers. However, the physical attributes of the premetastatic microenvironment …