The intricate microenvironment in which malignant cells reside is essential for the
progression of tumor growth. Both the physical and biochemical features of the tumor …

Within the ovarian cancer tumor microenvironment, cancer stem-like cells (CSC) interact
with carcinoma associated mesenchymal stem/stromal cells (CA-MSC) through multiple …

Cancer treatment development is a complex process, with tumor heterogeneity and inter-
patient variations limiting the success of therapeutic intervention. Traditional two …

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Among the key
challenges in developing effective therapeutics is the poor translation of preclinical models …

Simple Summary The Warburg effect in cancer cells (high glucose update and lactate
release) is an adaptation that is considered a hallmark of most neoplasms. Blocking …

Epithelial ovarian cancers are among the most aggressive forms of gynecological
malignancies. Despite the advent of poly adenosine diphosphate-ribose polymerase …

Nanoparticle drug delivery has been promoted as an effective mode of delivering
antineoplastic therapeutics. However, most nanoparticle designs fail to consider the …

Cancer stem-like cells (CSC) are responsible for tumor progression, chemoresistance,
recurrence, and poor outcomes in many cancers, making them critical research and …

Multicellular spheroids are superior to other culture geometries in reproducing critical
physiological conditions of tumors, such as the diffusion of oxygen, nutrients, waste, and …

Tissue-specific microenvironmental factors contribute to the targeting preferences of
metastatic cancers. However, the physical attributes of the premetastatic microenvironment …